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ROCK STUDY in CF: sustained anti-inflammatory effects of lumacaftor-ivacaftor in sputum and peripheral blood samples of adult patients with cystic fibrosis-an observational study.

Morrissy, David V
; 
McCarthy, Mairead
; 
Eustace, Joseph A
; 
Murphy, Desmond M
; 
Plant, B J
; ; ; ; ; 
Authors
Morrissy, David V
 McCarthy, Mairead
 Eustace, Joseph A
 Murphy, Desmond M
 Plant, B J
 Arooj, Parniya
 McCarthy, Yvonne
 Vagg, Tamara
 Fleming, Claire
 Daly, Mary
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Date
2023-05
Date Submitted
Keywords
cystic fibrosis
inflammation
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Principal Investigators
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bmjresp-2022-001590.pdf
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http://hdl.handle.net/10147/638413
Abstract
Previous studies showed that the combination of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) corrector and potentiator, lumacaftor-ivacaftor (LUMA-IVA) provides meaningful clinical benefits in patients with cystic fibrosis who are homozygous for the Phe508del CFTR mutation. However, little is known about the effect of LUMA-IVA on Proinflammatory Cytokines (PICs).
Language
en
Citation
ISSN
eISSN
2052-4439
ISBN
DOI
10.1136/bmjresp-2022-001590
PMID
37130650
PMCID
PMC10163494
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Ethical Approval