HSE Health Service Executive Lenus Repository

 

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Ireland's central source for Open Access health research

Lenus, the Irish Health Research repository is the leading source for Irish research in health and social care.  The Lenus collections include peer reviewed journal articles, grey literature, dissertations, reports and conference presentations. Lenus contains the publications of the Irish Health Service Executive (HSE) and the collected research output of over 130 health organisations past and present are all freely accessible.

Submit Your Research to Lenus 

If you are an Irish researcher or have conducted research in an Irish institution or health organisation, you can add your published research to Lenus. Submitted articles must be available in Open Access format or the publisher's policy must permit author self archiving. Advice on Open Access publishing and publishers' policies is available on the 'Open Access Publishing Guide' and 'Publishers' policies' pages available on the left-hand menu.     

SUBMIT HERE

 

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ORCIDs are a form of persistent unique identifier that gather all your published research together and link it unambiguously with you. Having an ORCID means eliminating confusion with similarly-named authors, and allows you to list all past affiliations, funding details and publications. Click here to get your free ORCID today.

 

HSE Open Access Research Awards 2022

The 9th annual HSE Open Access Research Awards are now open for entry.

The awards celebrate practitioners and researchers working across health and social care disciplines in Ireland who are publishing and making their research available in Open Access format.

 

The awards are judged across a number of categories, and for 2022 the categories are:

 

Acute Care and Hospitals

Community and Social Care

Mental Health and Disabilities

Integrated Services

Climate or Environmental Health

 

Entries will be reviewed by a panel of judges with research experience. There will be a prize for each category, and an overall winner will also be selected as representing the best of all submissions received.

 

This year there will be a special Innovation prize to recognise outstanding developments in practice or service delivery.

 

Winners will receive a custom piece of glassware celebrating their achievement.   

 

Criteria for Entry

Entries must fulfil the following criteria:

 

  • The research must have been published within the past two years (24 months)
  • The research must be available in full text in an Open Access forum (and added to the Lenus repository as a condition of entry)
  • At least one author must be working for or on behalf of the health services

 

Entries close on Friday October 28th 2022 and the winners will be announced in early December. Enquiries about the awards can be directed to lenus@hse.ie.   

Enter Now

 

 

 


 

 

 

 

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  • Persistent sodium currents in developmental and degenerative epileptic dyskinetic encephalopathy.

    Gorman, Kathleen M; Peters, Colin H; Lynch, Bryan; Jones, Laura; Bassett, Dani S; King, Mary D; Ruben, Peter C; Rosch, Richard E (2021-10-07)
    Pathogenic variants in the voltage-gated sodium channel gene (SCN1A) are amongst the most common genetic causes of childhood epilepsies. There is considerable heterogeneity in both the types of causative variants and associated phenotypes; a recent expansion of the phenotypic spectrum of SCN1A associated epilepsies now includes an early onset severe developmental and epileptic encephalopathy with regression and a hyperkinetic movement disorder. Herein, we report a female with a developmental and degenerative epileptic-dyskinetic encephalopathy, distinct and more severe than classic Dravet syndrome. Clinical diagnostics indicated a paternally inherited c.5053G>T; p. A1685S variant of uncertain significance in SCN1A. Whole-exome sequencing detected a second de novo mosaic (18%) c.2345G>A; p. T782I likely pathogenic variant in SCN1A (maternal allele). Biophysical characterization of both mutant channels in a heterologous expression system identified gain-of-function effects in both, with a milder shift in fast inactivation of the p. A1685S channels; and a more severe persistent sodium current in the p. T782I. Using computational models, we show that large persistent sodium currents induce hyper-excitability in individual cortical neurons, thus relating the severe phenotype to the empirically quantified sodium channel dysfunction. These findings further broaden the phenotypic spectrum of SCN1A associated epilepsies and highlight the importance of testing for mosaicism in epileptic encephalopathies. Detailed biophysical evaluation and computational modelling further highlight the role of gain-of-function variants in the pathophysiology of the most severe phenotypes associated with SCN1A.
  • Point-of-care testing in Paediatric settings in the UK and Ireland: a cross-sectional study.

    Pandey, Meenu; Lyttle, Mark D; Cathie, Katrina; Munro, Alasdair; Waterfield, Thomas; Roland, Damian (2022-01-11)
    Background: Point-of-care testing (POCT) is diagnostic testing performed at or near to the site of the patient. Understanding the current capacity, and scope, of POCT in this setting is essential in order to respond to new research evidence which may lead to wide implementation. Methods: A cross-sectional online survey study of POCT use was conducted between 6th January and 2nd February 2020 on behalf of two United Kingdom (UK) and Ireland-based paediatric research networks (Paediatric Emergency Research UK and Ireland, and General and Adolescent Paediatric Research UK and Ireland). Results: In total 91/109 (83.5%) sites responded, with some respondents providing details for multiple units on their site based on network membership (139 units in total). The most commonly performed POCT were blood sugar (137/139; 98.6%), urinalysis (134/139; 96.4%) and blood gas analysis (132/139; 95%). The use of POCT for Influenza/Respiratory Syncytial Virus (RSV) (45/139; 32.4%, 41/139; 29.5%), C-Reactive Protein (CRP) (13/139; 9.4%), Procalcitonin (PCT) (2/139; 1.4%) and Group A Streptococcus (5/139; 3.6%) and was relatively low. Obstacles to the introduction of new POCT included resources and infrastructure to support test performance and quality assurance. Conclusion: This survey demonstrates significant consensus in POCT practice in the UK and Ireland but highlights specific inequity in newer biomarkers, some which do not have support from national guidance. A clear strategy to overcome the key obstacles of funding, evidence base, and standardising variation will be essential if there is a drive toward increasing implementation of POCT.
  • Consultation-Liaison Psychiatry Services in Ireland: A National Cross-Sectional Study.

    Doherty, Anne M; Plunkett, Rosie; McEvoy, Katherine; Kelleher, Eric; Clancy, Maurice; Barrett, Elizabeth; Greene, Elaine; Cassidy, Eugene; Lee, William; MacHale, Siobhan (2021-11-29)
    Objective: This study aimed to describe the provision of consultation-liaison psychiatry (CLP, also known as liaison psychiatry) services in acute hospitals in Ireland, and to measure it against recommended resourcing levels. Methods: This is a survey of all acute hospitals in Ireland with Emergency Departments, via an electronic survey sent by email and followed up by telephone calls for missing data. Data were collected on service configuration, activity, and resourcing. Data were collected from CLP or proxy services at all acute hospitals with an Emergency Department in Ireland (n = 29). This study measured staffing and activity levels where available. Results: None of the services met the minimum criteria set out by either national or international guidance per 500 bed general hospital. Conclusions: CLP is a relatively new specialty in Ireland, but there are clear international guidelines about the staffing levels required to run these services safely and effectively. In Ireland, despite clear national guidance on staffing levels, no services are staffed to the levels suggested as the minimum. It is likely that patients in Ireland's acute hospitals have worse outcomes, and hospitals have unnecessary costs, due to this lack. This is the first study of CLP provision in Ireland and demonstrates the resource constraints under which most services work and the heterogeneity of services nationally.
  • The Role of the European Society of Human Genetics in Delivering Genomic Education.

    Tobias, Edward S; Avram, Elena; Calapod, Patricia; Cordier, Christophe; den Dunnen, Johan T; Ding, Can; Dolzan, Vita; Houge, Sofia Douzgou; Lynch, Sally Ann; O'Byrne, James; et al. (2021-09-03)
    The European Society of Human Genetics (ESHG) was founded in 1967 as a professional organisation for members working in genetics in clinical practice, research and education. The Society seeks the integration of scientific research and its implementation into clinical practice and the education of specialists and the public in all areas of medical and human genetics. The Society works to do this through many approaches, including educational sessions at the annual conference; training courses in general and specialist areas of genetics; an online resource of educational materials (EuroGEMS); and a mentorship scheme. The ESHG Education Committee is implementing new approaches to expand the reach of its educational activities and portfolio. With changes in technology, appreciation of the utility of genomics in healthcare and the public's and patients' increased awareness of the role of genomics, this review will summarise how the ESHG is adapting to deliver innovative educational activity.
  • Paediatric Dupuytren's Disease in a Child of Indian Ethnicity: A Case Report and Literature Review.

    Beecher, Suzanne M; Jeantet, Quentin; Cronin, Kevin J (2021-12-15)
    Paediatric Dupuytren's disease is a very rare clinical entity. Dupuytren's disease has preponderance to older males of Celtic heritage. We present a case of Dupuytren's disease in an eight-year-old boy of Indian ethnicity who presented with a progressive flexion contracture of his right ring finger for a duration of six months. On examination, he had an isolated 60-degree flexion contracture of the proximal interphalangeal joint with thickening of the skin and subcutaneous tissues. This was consistent with Dupuytren's cord and contracture. He proceeded to theatre for a dermofasciectomy, with subsequent histological confirmation of Dupuytren's disease. We performed a review of the literature and identified 21 reported cases of Dupuytren's disease affecting the hand in the paediatric population. This is a rare report of Dupuytren's disease affecting a child of Indian ethnicity.

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