Ireland's central source for Open Access health research
Lenus, the Irish Health Research repository is the leading source for Irish research in health and social care. The Lenus collections include peer reviewed journal articles, grey literature, dissertations, reports and conference presentations. Lenus contains the publications of the Irish Health Service Executive (HSE) and the collected research output of over 130 health organisations past and present are all freely accessible.
If you are an Irish researcher or have conducted research in an Irish institution or health organisation, you can add your published research to Lenus. Submitted articles must be available in Open Access format or the publisher's policy must permit author self archiving. Advice on Open Access publishing and publishers' policies is available on the 'Open Access Publishing Guide' and 'Publishers' policies' pages available on the left-hand menu.
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ORCIDs are a form of persistent unique identifier that gather all your published research together and link it unambiguously with you. Having an ORCID means eliminating confusion with similarly-named authors, and allows you to list all past affiliations, funding details and publications. Click here to get your free ORCID today.
HSE Open Access Research Awards 2021
The winners of the 2021 HSE Open Access Research Awards have been announced.
This year has seen the highest volume of entries in the history of the awards, reflecting the growth of Open Access publishing and the level of activity in Irish health research.
This year's awards were in four categories:
Acute Care and Hospitals
Colum Dunne et al Biomarkers in delirium: A systematic review
Community and Social Care
Mental Health and Disabilities
A Special Merit prize was awarded to:
The overall winner of the HSE Open Access Research Awards 2021 was:
Kieran Walsh et al. SARS-CoV-2 detection, viral load and infectivity over the course of an infection
Congratulations to our winners, and sincere thanks to all who entered their research for the awards.
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Communities in Lenus
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Human Monocyte Subset Distinctions and Function: Insights From Gene Expression Analysis.Monocytes are a highly plastic innate immune cell population that displays significant heterogeneity within the circulation. Distinct patterns of surface marker expression have become accepted as a basis for distinguishing three monocyte subsets in humans. These phenotypic subsets, termed classical, intermediate and nonclassical, have also been demonstrated to differ in regard to their functional properties and disease associations when studied in vitro and in vivo. Nonetheless, for the intermediate monocyte subset in particular, functional experiments have yielded conflicting results and some studies point to further levels of heterogeneity. Developments in genetic sequencing technology have provided opportunities to more comprehensively explore the phenotypic and functional differences among conventionally-recognized immune cell subtypes as well as the potential to identify novel subpopulations. In this review, we summarize the transcriptomic evidence in support of the existence of three separate monocyte subsets. We also critically evaluate the insights into subset functional distinctions that have been garnered from monocyte gene expression analysis and the potential utility of such studies to unravel subset-specific functional changes which arise in disease states.