Ireland's central source for Open Access health research
Lenus, the Irish Health Research repository is the leading source for Irish research in health and social care. The Lenus collections include peer reviewed journal articles, grey literature, dissertations, reports and conference presentations. Lenus contains the publications of the Irish Health Service Executive (HSE) and the collected research output of over 130 health organisations past and present are all freely accessible.
If you are an Irish researcher or have conducted research in an Irish institution or health organisation, you can add your published research to Lenus. Submitted articles must be available in Open Access format or the publisher's policy must permit author self archiving. Advice on Open Access publishing and publishers' policies is available on the 'Open Access Publishing Guide' and 'Publishers' policies' pages available on the left-hand menu.
HSE Open Access Research Awards 2021 - Enter Now
We are pleased to announce that the 2021 HSE Open Access Research Awards are now open.
This year has seen the Irish health services deal with a number of unprecedented challenges, from the massive cyber-attack in May to the rollout of the largest vaccination programme in the country’s history.
Through it all, clinicians and researchers have continued to deliver high quality healthcare – and to research new treatments, new advances in science and health, new ways of improving health outcomes.
The HSE Open Access Research Awards aims to shine a light on this activity and to thank those who have chosen to make their work available through Open Access, making their discoveries and advances freely available to all.
This year's awards will be in four categories:
Acute Care and Hospitals
Community and Social Care
Mental Health and Disabilities
Criteria for entry
Entries must fulfil the following criteria:
- The research must have been published within the past two years (24 months)
- The research must be available in full text in an Open Access forum (and added to the Lenus repository, pre or post entry)
The closing date for entries is Friday October 29th 2021, and the winners will be announced in early December. Enquiries about the awards can be directed to email@example.com.
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Communities in Lenus
Select a community to browse its collections.
Microglial Phenotypes and Their Relationship to the Cannabinoid System: Therapeutic Implications for Parkinson's Disease.Parkinson's disease is a neurodegenerative disorder, the motor symptoms of which are associated classically with Lewy body formation and nigrostriatal degeneration. Neuroinflammation has been implicated in the progression of this disease, by which microglia become chronically activated in response to α-synuclein pathology and dying neurons, thereby acquiring dishomeostatic phenotypes that are cytotoxic and can cause further neuronal death. Microglia have a functional endocannabinoid signaling system, expressing the cannabinoid receptors in addition to being capable of synthesizing and degrading endocannabinoids. Alterations in the cannabinoid system-particularly an upregulation in the immunomodulatory CB2 receptor-have been demonstrated to be related to the microglial activation state and hence the microglial phenotype. This paper will review studies that examine the relationship between the cannabinoid system and microglial activation, and how this association could be manipulated for therapeutic benefit in Parkinson's disease.