HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.
Authors
McCormack, MarkAlfirevic, Ana
Bourgeois, Stephane
Farrell, John J
Kasperavičiūtė, Dalia
Carrington, Mary
Sills, Graeme J
Marson, Tony
Jia, Xiaoming
de Bakker, Paul I W
Chinthapalli, Krishna
Molokhia, Mariam
Johnson, Michael R
O'Connor, Gerard D
Chaila, Elijah
Alhusaini, Saud
Shianna, Kevin V
Radtke, Rodney A
Heinzen, Erin L
Walley, Nicole
Pandolfo, Massimo
Pichler, Werner
Park, B Kevin
Depondt, Chantal
Sisodiya, Sanjay M
Goldstein, David B
Deloukas, Panos
Delanty, Norman
Cavalleri, Gianpiero L
Pirmohamed, Munir
Affiliation
Molecular and Cellular Therapeutics, the Royal College of Surgeons in Ireland, Dublin, Ireland.Issue Date
2011-03-24MeSH
AnticonvulsantsCarbamazepine
Drug Hypersensitivity
European Continental Ancestry Group
Exanthema
Genome-Wide Association Study
Genotype
HLA-A Antigens
Histocompatibility Testing
Humans
Polymorphism, Single Nucleotide
Stevens-Johnson Syndrome
Metadata
Show full item recordCitation
HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. 2011, 364 (12):1134-43 N. Engl. J. Med.Journal
The New England journal of medicineDOI
10.1056/NEJMoa1013297PubMed ID
21428769Abstract
Carbamazepine causes various forms of hypersensitivity reactions, ranging from maculopapular exanthema to severe blistering reactions. The HLA-B*1502 allele has been shown to be strongly correlated with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) in the Han Chinese and other Asian populations but not in European populations.Item Type
ArticleLanguage
enISSN
1533-4406ae974a485f413a2113503eed53cd6c53
10.1056/NEJMoa1013297