The association between change in body mass index and upper aerodigestive tract cancers in the ARCAGE project: multicenter case-control study.
Authors
Park, Sungshim LaniLee, Yuan-Chin Amy
Marron, Manuela
Agudo, Antonio
Ahrens, Wolfgang
Barzan, Luigi
Bencko, Vladimir
Benhamou, Simone
Bouchardy, Christine
Canova, Cristina
Castellsague, Xavier
Conway, David I
Healy, Claire M
Holcátová, Ivana
Kjaerheim, Kristina
Lagiou, Pagona
Lowry, Raymond J
Macfarlane, Tatiana V
Macfarlane, Gary J
McCartan, Bernard E
McKinney, Patricia A
Merletti, Franco
Pohlabeln, Hermann
Richiardi, Lorenzo
Simonato, Lorenzo
Sneddon, Linda
Talamini, Renato
Trichopoulos, Dimitrios
Znaor, Ariana
Brennan, Paul
Hashibe, Mia
Affiliation
Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA, USA.Issue Date
2011-03-15MeSH
AdultAged
Alcohol Drinking
Body Mass Index
Case-Control Studies
Esophageal Neoplasms
Europe
Female
Fruit
Humans
Laryngeal Neoplasms
Male
Middle Aged
Mouth Neoplasms
Prognosis
Risk Factors
Smoking
Metadata
Show full item recordCitation
The association between change in body mass index and upper aerodigestive tract cancers in the ARCAGE project: multicenter case-control study. 2011, 128 (6):1449-61 Int. J. CancerJournal
International journal of cancer. Journal international du cancerDOI
10.1002/ijc.25468PubMed ID
20506380Abstract
Previous studies reported an inverse relationship between body mass index (BMI) and upper aerodigestive tract (UADT) cancers. Examining change in BMI over time may clarify these previous observations. We used data from 2,048 cases and 2,173 hospital- and population-based controls from ten European countries (alcohol-related cancers and genetic susceptibility in Europe study) to investigate the relationship with BMI and adult change in BMI on UADT cancer risk. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for associations between BMI at three time intervals and BMI change on UADT cancer development, adjusting for center, age, sex, education, fruit and vegetable intake, smoking and alcohol consumption. We found an inverse relationship between UADT cancers and BMI at time of interview and 2 years before interview. No association was found with BMI at 30 years of age. Regarding BMI change between age 30 and 2 years before interview, BMI decrease (BMI change <-5%) vs. BMI stability (-5% ≤ BMI change <5%) showed no overall association with UADT cancers (OR = 1.15; 95% CI = 0.89, 1.49). An increase in BMI (BMI change ≥+5%) was inversely associated with UADT cancers (OR = 0.74; 95% CI = 0.62, 0.89). BMI gain remained inversely associated across all subsites except for esophageal cancer. When stratified by smoking or by drinking, association with BMI gain was detected only in drinkers and smokers. In conclusion, BMI gain is inversely associated with UADT cancers. These findings may be influenced by smoking and/or drinking behaviors and/or the development of preclinical UADT cancers and should be corroborated in studies of a prospective nature.Item Type
ArticleLanguage
enISSN
1097-0215ae974a485f413a2113503eed53cd6c53
10.1002/ijc.25468
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