Publication

The association between change in body mass index and upper aerodigestive tract cancers in the ARCAGE project: multicenter case-control study.

Park, Sungshim Lani
; 
Lee, Yuan-Chin Amy
; 
Marron, Manuela
; 
Agudo, Antonio
; 
Ahrens, Wolfgang
; 
Barzan, Luigi
; 
Bencko, Vladimir
; 
Benhamou, Simone
; 
Bouchardy, Christine
; 
Canova, Cristina
... show 10 more
Authors
Park, Sungshim Lani
 Lee, Yuan-Chin Amy
 Marron, Manuela
 Agudo, Antonio
 Ahrens, Wolfgang
 Barzan, Luigi
 Bencko, Vladimir
 Benhamou, Simone
 Bouchardy, Christine
 Canova, Cristina
 Castellsague, Xavier
 Conway, David I
 Healy, Claire M
 Holcátová, Ivana
 Kjaerheim, Kristina
 Lagiou, Pagona
 Lowry, Raymond J
 Macfarlane, Tatiana V
 Macfarlane, Gary J
 McCartan, Bernard E
 McKinney, Patricia A
 Merletti, Franco
 Pohlabeln, Hermann
 Richiardi, Lorenzo
 Simonato, Lorenzo
 Sneddon, Linda
 Talamini, Renato
 Trichopoulos, Dimitrios
 Znaor, Ariana
 Brennan, Paul
 Hashibe, Mia
Advisors
Editors
Other Contributors
Departments
Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA, USA.
Date
2011-03-15
Date Submitted
Keywords
Other Subjects
Subject Mesh
Adult
Aged
Alcohol Drinking
Body Mass Index
Case-Control Studies
Esophageal Neoplasms
Europe
Female
Fruit
Humans
Laryngeal Neoplasms
Male
Middle Aged
Mouth Neoplasms
Prognosis
Risk Factors
Smoking
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
URI
http://hdl.handle.net/10147/221857
Abstract
Previous studies reported an inverse relationship between body mass index (BMI) and upper aerodigestive tract (UADT) cancers. Examining change in BMI over time may clarify these previous observations. We used data from 2,048 cases and 2,173 hospital- and population-based controls from ten European countries (alcohol-related cancers and genetic susceptibility in Europe study) to investigate the relationship with BMI and adult change in BMI on UADT cancer risk. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for associations between BMI at three time intervals and BMI change on UADT cancer development, adjusting for center, age, sex, education, fruit and vegetable intake, smoking and alcohol consumption. We found an inverse relationship between UADT cancers and BMI at time of interview and 2 years before interview. No association was found with BMI at 30 years of age. Regarding BMI change between age 30 and 2 years before interview, BMI decrease (BMI change <-5%) vs. BMI stability (-5% ≤ BMI change <5%) showed no overall association with UADT cancers (OR = 1.15; 95% CI = 0.89, 1.49). An increase in BMI (BMI change ≥+5%) was inversely associated with UADT cancers (OR = 0.74; 95% CI = 0.62, 0.89). BMI gain remained inversely associated across all subsites except for esophageal cancer. When stratified by smoking or by drinking, association with BMI gain was detected only in drinkers and smokers. In conclusion, BMI gain is inversely associated with UADT cancers. These findings may be influenced by smoking and/or drinking behaviors and/or the development of preclinical UADT cancers and should be corroborated in studies of a prospective nature.
Language
en
Citation
The association between change in body mass index and upper aerodigestive tract cancers in the ARCAGE project: multicenter case-control study. 2011, 128 (6):1449-61 Int. J. Cancer
ISSN
1097-0215
eISSN
ISBN
DOI
10.1002/ijc.25468
PMID
20506380
PMCID
Sponsorships
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