Emwas, Abdul-Hamid MAl-Rifai, NahlaSzczepski, KacperAlsuhaymi, ShuruqRayyan, SalehAlmahasheer, HananJaremko, MariuszBrennan, LorraineLachowicz, Joanna Izabela2022-02-072022-02-072021-05-312304-81583407278010.3390/foods10061249http://hdl.handle.net/10147/631350Full text links full text provider logo Actions Favorites Share Page navigation Title & authors Abstract Conflict of interest statement Figures Similar articles References Publication types LinkOut - more resources Review Foods . 2021 May 31;10(6):1249. doi: 10.3390/foods10061249. You Are What You Eat: Application of Metabolomics Approaches to Advance Nutrition Research Abdul-Hamid M Emwas 1 , Nahla Al-Rifai 2 , Kacper Szczepski 3 , Shuruq Alsuhaymi 3 , Saleh Rayyan 4 , Hanan Almahasheer 5 , Mariusz Jaremko 3 , Lorraine Brennan 6 , Joanna Izabela Lachowicz 7 Affiliations Affiliations 1 Imaging and Characterization Core Lab, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia. 2 Should be: Environmental Technology Management (2005-2012), College for Women, Kuwait University, P.O. Box 5969, Safat 13060, Kuwait. 3 Biological and Environmental Sciences & Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia. 4 Chemistry Department, Birzeit University, Birzeit 627, Palestine. 5 Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University (IAU), Dammam 31441-1982, Saudi Arabia. 6 Institute of Food and Health and Conway Institute, School of Agriculture & Food Science, Dublin 4, Ireland. 7 Department of Medical Sciences and Public Health, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy. PMID: 34072780 PMCID: PMC8229064 DOI: 10.3390/foods10061249 Free PMC article Abstract A healthy condition is defined by complex human metabolic pathways that only function properly when fully satisfied by nutritional inputs. Poor nutritional intakes are associated with a number of metabolic diseases, such as diabetes, obesity, atherosclerosis, hypertension, and osteoporosis. In recent years, nutrition science has undergone an extraordinary transformation driven by the development of innovative software and analytical platforms. However, the complexity and variety of the chemical components present in different food types, and the diversity of interactions in the biochemical networks and biological systems, makes nutrition research a complicated field. Metabolomics science is an "-omic", joining proteomics, transcriptomics, and genomics in affording a global understanding of biological systems. In this review, we present the main metabolomics approaches, and highlight the applications and the potential for metabolomics approaches in advancing nutritional food research.enMSNMRFOODmetabolomicsNUTRITIONArticleFoods (Basel, Switzerland)