This item is non-discoverable
Non-discoverable
Hepatitis C virus-associated thrombocytopenia in pregnancy: impact upon multidisciplinary care provision.
Monteith, Cathy Ní Ainle, Fionnuala Cooley, Sharon Lambert, John S Kelleher, Barry Jackson, Valerie Eogan, Maeve
Monteith, Cathy
Ní Ainle, Fionnuala
Cooley, Sharon
Lambert, John S
Kelleher, Barry
Jackson, Valerie
Eogan, Maeve
Advisors
Editors
Other Contributors
Departments
Date
2014-01-01
Date Submitted
Keywords
HEPATITIS C
PREGNANCY
PREGNANCY
Other Subjects
THROMBOCYTOPENIA
Subject Mesh
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
Abstract Objective: Recent studies have implicated hepatitis C virus (HCV) in the pathogenesis of immune thrombocytopenia. In pregnancy-associated immune thrombocytopenia, multidisciplinary management is required due to a potential for bleeding complications. We performed a retrospective review of HCV-infected pregnant women and age-matched controls who were not infected with HCV. Methods: One hundred and six women with a HCV viral load were identified from 2009 to 2011. Results: Thrombocytopenia was identified in 10.3% of HCV-infected pregnant women and 1.6% of age-matched controls (P<0.001). Mean platelet count during pregnancy was 120±23×109/L in HCV-infected women and at delivery was significantly lower in HCV-infected women than in controls (P=0.01). Despite the significant difference in platelet counts, there was no significant difference in estimated blood loss (EBL) at delivery. Regional anaesthesia was performed in 73% of thrombocytopenic HCV-infected women and no complications were recorded. There were no fetal bleeding complications. Conclusion: In the first study to date to investigate the impact of HCV on maternal platelet count we demonstrated a significantly higher frequency of thrombocytopenia and a significantly lower platelet count in HCV-infected pregnant women compared with controls. Interestingly, thrombocytopenia had no detectable impact on EBL at delivery.
Language
en
ISSN
1619-3997
eISSN
ISBN
DOI
10.1515/jpm-2013-0080
PMID
24006316