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    Antiangiogenic therapy in lung cancer: focus on vascular endothelial growth factor pathway.

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    Authors
    Korpanty, Grzegorz
    Smyth, Elizabeth
    Sullivan, Laura A
    Brekken, Rolf A
    Carney, Desmond N
    Affiliation
    Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St, Dublin 7, Ireland. greg.korpanty@gmail.com
    Issue Date
    2010-01
    MeSH
    Angiogenesis Inhibitors
    Antibodies, Monoclonal
    Carcinoma, Non-Small-Cell Lung
    Clinical Trials as Topic
    Humans
    Lung Neoplasms
    Neovascularization, Pathologic
    Piperidines
    Quinazolines
    Receptor, Epidermal Growth Factor
    Receptors, Vascular Endothelial Growth Factor
    Vascular Endothelial Growth Factor A
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    Citation
    Antiangiogenic therapy in lung cancer: focus on vascular endothelial growth factor pathway. 2010, 235 (1):3-9 Exp. Biol. Med. (Maywood)
    Journal
    Experimental biology and medicine (Maywood, N.J.)
    URI
    http://hdl.handle.net/10147/99108
    DOI
    10.1258/ebm.2009.009191
    PubMed ID
    20404013
    Abstract
    Lung cancer (LC) is a leading cause of death worldwide. Recent advances in chemotherapeutic agents have not yielded any significant improvement in the prognosis of patients with LC. The five-year survival rate for all combined disease stages remains about 15%. For this reason, new therapies such as those that inhibit tumor angiogenesis or block activity of growth factor receptors are of special interest in this group of patients. In this review we will summarize the most recent clinical data on biologic therapies that inhibit tumor angiogenesis in LC, focusing on those that are most clinically relevant.
    Item Type
    Preprint
    Language
    en
    ISSN
    1535-3699
    ae974a485f413a2113503eed53cd6c53
    10.1258/ebm.2009.009191
    Scopus Count
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