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    A Prospective Study of Pravastatin in the Elderly at Risk (PROSPER): Screening Experience and Baseline Characteristics.

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    Authors
    Ford, Ian
    Blauw, Gerard Jan
    Murphy, Michael B
    Shepherd, James
    Cobbe, Stuart M
    Bollen, Edward LEM
    Buckley, Brendan M
    Jukema, J Wouter
    Hyland, Michael
    Gaw, Allan
    Lagaay, A Margot
    Perry, Ivan J
    Macfarlane, Peter
    Norrie, John
    Meinders, A Edo
    Sweeney, Brian J
    Packard, Chris J
    Westendorp, Rudi GJ
    Twomey, Cillian
    Stott, David J
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    Affiliation
    University of Glasgow, Scotland. ian@stats.gla.ac.uk
    Issue Date
    2002-05-20
    
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    Citation
    A Prospective Study of Pravastatin in the Elderly at Risk (PROSPER): Screening Experience and Baseline Characteristics. 2002, 3 (1):8 Curr Control Trials Cardiovasc Med
    Journal
    Current controlled trials in cardiovascular medicine
    URI
    http://hdl.handle.net/10147/95637
    DOI
    10.1186/1468-6708-3-8
    PubMed ID
    12097148
    Abstract
    BACKGROUND: PROSPER was designed to investigate the benefits of treatment with pravastatin in elderly patients for whom a typical doctor might consider the prescription of statin therapy to be a realistic option. METHODS: The PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) is a randomised, double blind, placebo-controlled trial to test the hypothesis that treatment with pravastatin (40 mg/day) will reduce the risk of coronary heart disease death, non-fatal myocardial infarction, and fatal or non-fatal stroke in elderly men and women with pre-existing vascular disease or with significant risk of developing this condition. RESULTS: In Scotland, Ireland, and the Netherlands, 23,770 individuals were screened, and 5,804 subjects (2,804 men and 3,000 women), aged 70 to 82 years (average 75 years) and with baseline cholesterol 4.0-9.0 mmol/l, were randomised. Randomised subjects had similar distributions with respect to age, blood pressure, and body mass index when compared to the entire group of screenees, but had a higher prevalence of smoking, diabetes, hypertension, and a history of vascular disease. The average total cholesterol level at baseline was 5.4 mmol/l (men) and 6.0 mmol/l (women). CONCLUSIONS: Compared with previous prevention trials of cholesterol-lowering drugs, the PROSPER cohort is significantly older and for the first time includes a majority of women. The study, having achieved its initial goal of recruiting more than 5,500 elderly high-risk men and women, aims to complete all final subject follow-up visits in the first half of 2002 with the main results being available in the fourth quarter of 2002.
    ISSN
    1468-6694
    ae974a485f413a2113503eed53cd6c53
    10.1186/1468-6708-3-8
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    • Authors: Shepherd J, Blauw GJ, Murphy MB, Bollen EL, Buckley BM, Cobbe SM, Ford I, Gaw A, Hyland M, Jukema JW, Kamper AM, Macfarlane PW, Meinders AE, Norrie J, Packard CJ, Perry IJ, Stott DJ, Sweeney BJ, Twomey C, Westendorp RG, PROSPER study group. PROspective Study of Pravastatin in the Elderly at Risk
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