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    Quality of life of palliative chemotherapy naive patients with advanced adenocarcinoma of the stomach or esophagogastric junction treated with irinotecan combined with 5-fluorouracil and folinic acid: results of a randomised phase III trial.

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    Authors
    Curran, Desmond
    Pozzo, Carmelo
    Zaluski, Jerzy
    Dank, Magdalena
    Barone, Carlo
    Valvere, Vahur
    Yalcin, Suayib
    Peschel, Christian
    Wenczl, Miklós
    Goker, Erdem
    Bugat, Roland
    Show allShow less
    Affiliation
    Omega Research, Santry, Dublin 9, Ireland. currandes@omega-research.eu.com
    Issue Date
    2009-09
    MeSH
    Adenocarcinoma
    Adolescent
    Adult
    Aged
    Antineoplastic Combined Chemotherapy Protocols
    Camptothecin
    Cisplatin
    Esophagogastric Junction
    Fluorouracil
    Humans
    Leucovorin
    Middle Aged
    Neoplasm Metastasis
    Palliative Care
    Quality of Life
    Stomach Neoplasms
    Young Adult
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    Citation
    Quality of life of palliative chemotherapy naive patients with advanced adenocarcinoma of the stomach or esophagogastric junction treated with irinotecan combined with 5-fluorouracil and folinic acid: results of a randomised phase III trial. 2009, 18 (7):853-61 Qual Life Res
    Journal
    Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
    URI
    http://hdl.handle.net/10147/94216
    DOI
    10.1007/s11136-009-9493-z
    PubMed ID
    19568958
    Abstract
    PURPOSE: The quality of life (QL) of advanced gastric cancer patients receiving irinotecan, folinic acid and 5-fluorouracil (5-FU) (IF arm) or cisplatin with 5-FU (CF arm) is presented. METHODS: Patients with measurable or evaluable advanced gastric cancer received IF weekly for 6/7 weeks or CF q4 weeks. QL was assessed using the EORTC QLQ-C30 at baseline, subsequently every 8 weeks until progression and thereafter every 3 months until death. The QL data were analysed using several statistical methods including summary measures and pattern-mixture modelling. RESULTS: A total of 333 patients were randomised and treated (IF 170, CF 163). The time-to-progression for IF and CF was 5.0 and 4.2 months (P = 0.088), respectively. The overall compliance rates for QL questionnaire completion were 60 and 56% in the IF and CF arms, respectively. Significant treatment differences were observed for the physical functioning scale (P = 0.024), nausea\vomiting (P = 0.001) and EQ-5D thermometer (P = 0.020) in favour of the IF treatment arm. CONCLUSION: There was a trend in favour of IF over CF in time-to-progression. The IF group also demonstrated a better safety profile than CF and a better QL on a number of multi-item scales, suggesting that IF offers an alternative first-line platinum-free treatment option for advanced gastric cancer.
    Language
    en
    ISSN
    1573-2649
    ae974a485f413a2113503eed53cd6c53
    10.1007/s11136-009-9493-z
    Scopus Count
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