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dc.contributor.authorMolloy, Anne M
dc.contributor.authorQuadros, Edward V
dc.contributor.authorSequeira, Jeffrey M
dc.contributor.authorTroendle, James F
dc.contributor.authorScott, John M
dc.contributor.authorKirke, Peadar N
dc.contributor.authorMills, James L
dc.date.accessioned2010-03-12T15:38:18Z
dc.date.available2010-03-12T15:38:18Z
dc.date.issued2009-07-09
dc.identifier.citationLack of association between folate-receptor autoantibodies and neural-tube defects. 2009, 361 (2):152-60 N. Engl. J. Med.en
dc.identifier.issn1533-4406
dc.identifier.pmid19587340
dc.identifier.doi10.1056/NEJMoa0803783
dc.identifier.urihttp://hdl.handle.net/10147/94213
dc.description.abstractBACKGROUND: A previous report described the presence of autoantibodies against folate receptors in 75% of serum samples from women with a history of pregnancy complicated by a neural-tube defect, as compared with 10% of controls. We sought to confirm this finding in an Irish population, which traditionally has had a high prevalence of neural-tube defects. METHODS: We performed two studies. Study 1 consisted of analysis of stored frozen blood samples collected from 1993 through 1994 from 103 mothers with a history of pregnancy complicated by a neural-tube defect (case mothers), 103 mothers with a history of pregnancy but no complication by a neural-tube defect (matched with regard to number of pregnancies and sampling dates), 58 women who had never been pregnant, and 36 men. Study 2, conducted to confirm that the storage of samples did not influence the folate-receptor autoantibodies, included fresh samples from 37 case mothers, 22 control mothers, 10 women who had never been pregnant, and 9 men. All samples were assayed for blocking and binding autoantibodies against folate receptors. RESULTS: In Study 1, blocking autoantibodies were found in 17% of case mothers, as compared with 13% of control mothers (odds ratio, 1.54; 95% confidence interval [CI], 0.70 to 3.39), and binding autoantibodies in 29%, as compared with 32%, respectively (odds ratio, 0.82; 95% CI, 0.44 to 1.50). Study 2 showed similar results, indicating that sample degradation was unlikely. CONCLUSIONS: The presence and titer of maternal folate-receptor autoantibodies were not significantly associated with a neural-tube defect-affected pregnancy in this Irish population.
dc.language.isoenen
dc.subject.meshAutoantibodies
dc.subject.meshCarrier Proteins
dc.subject.meshCase-Control Studies
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIreland
dc.subject.meshLogistic Models
dc.subject.meshMale
dc.subject.meshNeural Tube Defects
dc.subject.meshPregnancy
dc.subject.meshReceptors, Cell Surface
dc.titleLack of association between folate-receptor autoantibodies and neural-tube defects.en
dc.contributor.departmentSchool of Medicine, Trinity College, Dublin, Ireland. amolloy@tcd.ieen
dc.identifier.journalThe New England journal of medicineen
refterms.dateFOA2018-08-31T04:58:53Z
html.description.abstractBACKGROUND: A previous report described the presence of autoantibodies against folate receptors in 75% of serum samples from women with a history of pregnancy complicated by a neural-tube defect, as compared with 10% of controls. We sought to confirm this finding in an Irish population, which traditionally has had a high prevalence of neural-tube defects. METHODS: We performed two studies. Study 1 consisted of analysis of stored frozen blood samples collected from 1993 through 1994 from 103 mothers with a history of pregnancy complicated by a neural-tube defect (case mothers), 103 mothers with a history of pregnancy but no complication by a neural-tube defect (matched with regard to number of pregnancies and sampling dates), 58 women who had never been pregnant, and 36 men. Study 2, conducted to confirm that the storage of samples did not influence the folate-receptor autoantibodies, included fresh samples from 37 case mothers, 22 control mothers, 10 women who had never been pregnant, and 9 men. All samples were assayed for blocking and binding autoantibodies against folate receptors. RESULTS: In Study 1, blocking autoantibodies were found in 17% of case mothers, as compared with 13% of control mothers (odds ratio, 1.54; 95% confidence interval [CI], 0.70 to 3.39), and binding autoantibodies in 29%, as compared with 32%, respectively (odds ratio, 0.82; 95% CI, 0.44 to 1.50). Study 2 showed similar results, indicating that sample degradation was unlikely. CONCLUSIONS: The presence and titer of maternal folate-receptor autoantibodies were not significantly associated with a neural-tube defect-affected pregnancy in this Irish population.


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