Lack of association between folate-receptor autoantibodies and neural-tube defects.
Authors
Molloy, Anne MQuadros, Edward V
Sequeira, Jeffrey M
Troendle, James F
Scott, John M
Kirke, Peadar N
Mills, James L
Affiliation
School of Medicine, Trinity College, Dublin, Ireland. amolloy@tcd.ieIssue Date
2009-07-09MeSH
AutoantibodiesCarrier Proteins
Case-Control Studies
Female
Humans
Ireland
Logistic Models
Male
Neural Tube Defects
Pregnancy
Receptors, Cell Surface
Metadata
Show full item recordCitation
Lack of association between folate-receptor autoantibodies and neural-tube defects. 2009, 361 (2):152-60 N. Engl. J. Med.Journal
The New England journal of medicineDOI
10.1056/NEJMoa0803783PubMed ID
19587340Abstract
BACKGROUND: A previous report described the presence of autoantibodies against folate receptors in 75% of serum samples from women with a history of pregnancy complicated by a neural-tube defect, as compared with 10% of controls. We sought to confirm this finding in an Irish population, which traditionally has had a high prevalence of neural-tube defects. METHODS: We performed two studies. Study 1 consisted of analysis of stored frozen blood samples collected from 1993 through 1994 from 103 mothers with a history of pregnancy complicated by a neural-tube defect (case mothers), 103 mothers with a history of pregnancy but no complication by a neural-tube defect (matched with regard to number of pregnancies and sampling dates), 58 women who had never been pregnant, and 36 men. Study 2, conducted to confirm that the storage of samples did not influence the folate-receptor autoantibodies, included fresh samples from 37 case mothers, 22 control mothers, 10 women who had never been pregnant, and 9 men. All samples were assayed for blocking and binding autoantibodies against folate receptors. RESULTS: In Study 1, blocking autoantibodies were found in 17% of case mothers, as compared with 13% of control mothers (odds ratio, 1.54; 95% confidence interval [CI], 0.70 to 3.39), and binding autoantibodies in 29%, as compared with 32%, respectively (odds ratio, 0.82; 95% CI, 0.44 to 1.50). Study 2 showed similar results, indicating that sample degradation was unlikely. CONCLUSIONS: The presence and titer of maternal folate-receptor autoantibodies were not significantly associated with a neural-tube defect-affected pregnancy in this Irish population.Language
enISSN
1533-4406ae974a485f413a2113503eed53cd6c53
10.1056/NEJMoa0803783
Scopus Count
Collections
Related articles
- Autoantibodies against folate receptors in women with a pregnancy complicated by a neural-tube defect.
- Authors: Rothenberg SP, da Costa MP, Sequeira JM, Cracco J, Roberts JL, Weedon J, Quadros EV
- Issue date: 2004 Jan 8
- Autoantibodies to folate receptor during pregnancy and neural tube defect risk.
- Authors: Cabrera RM, Shaw GM, Ballard JL, Carmichael SL, Yang W, Lammer EJ, Finnell RH
- Issue date: 2008 Oct
- Lack of association between folate receptor autoantibodies and conotruncal congenital heart defects.
- Authors: Lewandowski LB, Sanghavi D
- Issue date: 2013 Mar
- Autoantibodies to folate receptor alpha during early pregnancy and risk of oral clefts in Denmark.
- Authors: Bille C, Pedersen DA, Andersen AM, Mansilla MA, Murray JC, Christensen K, Ballard JL, Gorman EB, Cabrera RM, Finnell RH
- Issue date: 2010 Mar
- Association between blocking folate receptor autoantibodies and subfertility.
- Authors: Berrocal-Zaragoza MI, Fernandez-Ballart JD, Murphy MM, Cavallé-Busquets P, Sequeira JM, Quadros EV
- Issue date: 2009 Apr