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    Lack of association between folate-receptor autoantibodies and neural-tube defects.

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    Authors
    Molloy, Anne M
    Quadros, Edward V
    Sequeira, Jeffrey M
    Troendle, James F
    Scott, John M
    Kirke, Peadar N
    Mills, James L
    Affiliation
    School of Medicine, Trinity College, Dublin, Ireland. amolloy@tcd.ie
    Issue Date
    2009-07-09
    MeSH
    Autoantibodies
    Carrier Proteins
    Case-Control Studies
    Female
    Humans
    Ireland
    Logistic Models
    Male
    Neural Tube Defects
    Pregnancy
    Receptors, Cell Surface
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    Citation
    Lack of association between folate-receptor autoantibodies and neural-tube defects. 2009, 361 (2):152-60 N. Engl. J. Med.
    Journal
    The New England journal of medicine
    URI
    http://hdl.handle.net/10147/94213
    DOI
    10.1056/NEJMoa0803783
    PubMed ID
    19587340
    Abstract
    BACKGROUND: A previous report described the presence of autoantibodies against folate receptors in 75% of serum samples from women with a history of pregnancy complicated by a neural-tube defect, as compared with 10% of controls. We sought to confirm this finding in an Irish population, which traditionally has had a high prevalence of neural-tube defects. METHODS: We performed two studies. Study 1 consisted of analysis of stored frozen blood samples collected from 1993 through 1994 from 103 mothers with a history of pregnancy complicated by a neural-tube defect (case mothers), 103 mothers with a history of pregnancy but no complication by a neural-tube defect (matched with regard to number of pregnancies and sampling dates), 58 women who had never been pregnant, and 36 men. Study 2, conducted to confirm that the storage of samples did not influence the folate-receptor autoantibodies, included fresh samples from 37 case mothers, 22 control mothers, 10 women who had never been pregnant, and 9 men. All samples were assayed for blocking and binding autoantibodies against folate receptors. RESULTS: In Study 1, blocking autoantibodies were found in 17% of case mothers, as compared with 13% of control mothers (odds ratio, 1.54; 95% confidence interval [CI], 0.70 to 3.39), and binding autoantibodies in 29%, as compared with 32%, respectively (odds ratio, 0.82; 95% CI, 0.44 to 1.50). Study 2 showed similar results, indicating that sample degradation was unlikely. CONCLUSIONS: The presence and titer of maternal folate-receptor autoantibodies were not significantly associated with a neural-tube defect-affected pregnancy in this Irish population.
    Language
    en
    ISSN
    1533-4406
    ae974a485f413a2113503eed53cd6c53
    10.1056/NEJMoa0803783
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