Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma.
Authors
Walsh, NaomiLarkin, Annemarie
Kennedy, Susan
Connolly, Lisa
Ballot, Jo
Ooi, Wei
Gullo, Giuseppe
Crown, John
Clynes, Martin
O'Driscoll, Lorraine
Affiliation
National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland. naomi.walsh@dcu.ieIssue Date
2009MeSH
AgedAged, 80 and over
Antineoplastic Agents
Carcinoma, Renal Cell
Female
Gene Expression Regulation, Neoplastic
Humans
Kidney Neoplasms
Male
Middle Aged
Multidrug Resistance-Associated Proteins
Neoplasm Proteins
P-Glycoprotein
Tumor Cells, Cultured
Tumor Markers, Biological
Metadata
Show full item recordCitation
Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma. 2009, 9:6 BMC UrolJournal
BMC urologyDOI
10.1186/1471-2490-9-6PubMed ID
19552816Abstract
BACKGROUND: Renal cell carcinoma patients respond poorly to conventional chemotherapy, this unresponsiveness may be attributable to multidrug resistance (MDR). The mechanisms of MDR in renal cancer are not fully understood and the specific contribution of ABC transporter proteins which have been implicated in the chemoresistance of various cancers has not been fully defined in this disease. METHODS: In this retrospective study the expression of two of these transporter efflux pumps, namely MDR-1 P-gp (ABCB1) and MRP-1 (ABCC1) were studied by immunohistochemistry in archival material from 95 renal cell carcinoma patients. RESULTS: In the first study investigating MDR-1 P-gp and MRP-1 protein expression patterns in renal cell carcinoma patients, high levels of expression of both efflux pumps are observed with 100% of tumours studied showing MDR-1 P-gp and MRP-1 positivity. CONCLUSION: Although these findings do not prove a causal role, the high frequency of tumours expressing these efflux pumps suggests that they may be important contributors to the chemoresistance of this tumour type.Language
enISSN
1471-2490ae974a485f413a2113503eed53cd6c53
10.1186/1471-2490-9-6