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    Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma.

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    Authors
    Walsh, Naomi
    Larkin, Annemarie
    Kennedy, Susan
    Connolly, Lisa
    Ballot, Jo
    Ooi, Wei
    Gullo, Giuseppe
    Crown, John
    Clynes, Martin
    O'Driscoll, Lorraine
    Affiliation
    National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland. naomi.walsh@dcu.ie
    Issue Date
    2009
    MeSH
    Aged
    Aged, 80 and over
    Antineoplastic Agents
    Carcinoma, Renal Cell
    Female
    Gene Expression Regulation, Neoplastic
    Humans
    Kidney Neoplasms
    Male
    Middle Aged
    Multidrug Resistance-Associated Proteins
    Neoplasm Proteins
    P-Glycoprotein
    Tumor Cells, Cultured
    Tumor Markers, Biological
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    Citation
    Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma. 2009, 9:6 BMC Urol
    Journal
    BMC urology
    URI
    http://hdl.handle.net/10147/94205
    DOI
    10.1186/1471-2490-9-6
    PubMed ID
    19552816
    Abstract
    BACKGROUND: Renal cell carcinoma patients respond poorly to conventional chemotherapy, this unresponsiveness may be attributable to multidrug resistance (MDR). The mechanisms of MDR in renal cancer are not fully understood and the specific contribution of ABC transporter proteins which have been implicated in the chemoresistance of various cancers has not been fully defined in this disease. METHODS: In this retrospective study the expression of two of these transporter efflux pumps, namely MDR-1 P-gp (ABCB1) and MRP-1 (ABCC1) were studied by immunohistochemistry in archival material from 95 renal cell carcinoma patients. RESULTS: In the first study investigating MDR-1 P-gp and MRP-1 protein expression patterns in renal cell carcinoma patients, high levels of expression of both efflux pumps are observed with 100% of tumours studied showing MDR-1 P-gp and MRP-1 positivity. CONCLUSION: Although these findings do not prove a causal role, the high frequency of tumours expressing these efflux pumps suggests that they may be important contributors to the chemoresistance of this tumour type.
    Language
    en
    ISSN
    1471-2490
    ae974a485f413a2113503eed53cd6c53
    10.1186/1471-2490-9-6
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