Authors
Chen, XiangningSun, Cuie
Chen, Qi
O'Neill, F Anthony
Walsh, Dermot
Fanous, Ayman H
Chowdari, Kodavali V
Nimgaonkar, Vishwajit L
Scott, Adrian
Schwab, Sibylle G
Wildenauer, Dieter B
Che, Ronglin
Tang, Wei
Shi, Yongyong
He, Lin
Luo, Xiong-Jian
Su, Bing
Edwards, Todd L
Zhao, Zhongming
Kendler, Kenneth S
Affiliation
Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, Virginia, USA. xchen@vcu.eduIssue Date
2009MeSH
ATP-Binding Cassette TransportersAdaptor Proteins, Signal Transducing
Apoptosis
Asian Continental Ancestry Group
China
Ethnic Groups
European Continental Ancestry Group
Gene Expression Profiling
Gene Expression Regulation
Genetic Markers
Genotype
Germany
Humans
Ireland
Membrane Proteins
Schizophrenia
United States
Metadata
Show full item recordCitation
Apoptotic engulfment pathway and schizophrenia. 2009, 4 (9):e6875 PLoS ONEJournal
PloS oneDOI
10.1371/journal.pone.0006875PubMed ID
19721717Abstract
BACKGROUND: Apoptosis has been speculated to be involved in schizophrenia. In a previously study, we reported the association of the MEGF10 gene with the disease. In this study, we followed the apoptotic engulfment pathway involving the MEGF10, GULP1, ABCA1 and ABCA7 genes and tested their association with the disease. METHODOLOGY/PRINCIPAL FINDINGS: Ten, eleven and five SNPs were genotyped in the GULP1, ABCA1 and ABCA7 genes respectively for the ISHDSF and ICCSS samples. In all 3 genes, we observed nominally significant associations. Rs2004888 at GULP1 was significant in both ISHDSF and ICCSS samples (p = 0.0083 and 0.0437 respectively). We sought replication in independent samples for this marker and found highly significant association (p = 0.0003) in 3 Caucasian replication samples. But it was not significant in the 2 Chinese replication samples. In addition, we found a significant 2-marker (rs2242436 * rs3858075) interaction between the ABCA1 and ABCA7 genes in the ISHDSF sample (p = 0.0022) and a 3-marker interaction (rs246896 * rs4522565 * rs3858075) amongst the MEGF10, GULP1 and ABCA1 genes in the ICCSS sample (p = 0.0120). Rs3858075 in the ABCA1 gene was involved in both 2- and 3-marker interactions in the two samples. CONCLUSIONS/SIGNIFICANCE: From these data, we concluded that the GULP1 gene and the apoptotic engulfment pathway are involved in schizophrenia in subjects of European ancestry and multiple genes in the pathway may interactively increase the risks to the disease.Language
enISSN
1932-6203ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0006875
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Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/
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