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    Sustained virologic response following HCV eradication in two brothers with X-linked agammaglobulinaemia.

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    Authors
    Houlihan, Diarmaid D
    Storan, Eoin R
    Lee, John M
    Affiliation
    Department of Gastroenterology, University College Hospital Galway, Newcastle Road, Galway, Ireland. diarmaidhoulihan@hotmail.com
    Issue Date
    2009-08-21
    MeSH
    Adult
    Agammaglobulinemia
    Antiviral Agents
    Comorbidity
    Drug Contamination
    Genetic Diseases, X-Linked
    Hepatitis C
    Humans
    Interferon Alfa-2b
    Male
    Recurrence
    Ribavirin
    Siblings
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    Citation
    Sustained virologic response following HCV eradication in two brothers with X-linked agammaglobulinaemia. 2009, 15 (31):3944-6 World J. Gastroenterol.
    Journal
    World journal of gastroenterology : WJG
    URI
    http://hdl.handle.net/10147/94023
    PubMed ID
    19701978
    Abstract
    X-linked agammaglobulinaemia (XLA) is a humoral immunodeficiency syndrome characterized from childhood by the absence of circulating B lymphocytes, absent or reduced levels of serum immunoglobulin and recurrent bacterial infections. For many affected patients, regular treatment with immunoglobulin is life saving. Hepatitis C viral (HCV) infection acquired through contaminated blood products is widely described in this patient cohort. The natural history of HCV infection in patients with XLA tends to follow a more rapid and aggressive course compared to immunocompetent individuals. Furthermore, standard anti-viral therapy appears to be less efficacious in this patient cohort. Here we report the cases of two brothers with XLA who contracted HCV through contaminated blood products. They were treated with a six month course of Interferon alpha-2b and Ribavirin. We report a sustained virologic response five years after completing treatment.
    Language
    en
    ISSN
    1007-9327
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