Prolonged rote learning produces delayed memory facilitation and metabolic changes in the hippocampus of the ageing human brain.
AuthorsRoche, Richard Ap
Mullally, Sinéad L
McNulty, Jonathan P
Doherty, Colin P
Mangaoang, Maeve A
Robertson, Ian H
O'Mara, Shane M
AffiliationSchool of Psychology & Trinity College Institute of Neuroscience, University of Dublin, Trinity College, Dublin 2, Ireland. Richard.Roche@nuim.ie
Analysis of Variance
Magnetic Resonance Spectroscopy
Signal Processing, Computer-Assisted
MetadataShow full item record
CitationProlonged rote learning produces delayed memory facilitation and metabolic changes in the hippocampus of the ageing human brain. 2009, 10:136 BMC Neurosci
AbstractBACKGROUND: Repeated rehearsal is one method by which verbal material may be transferred from short- to long-term memory. We hypothesised that extended engagement of memory structures through prolonged rehearsal would result in enhanced efficacy of recall and also of brain structures implicated in new learning. Twenty-four normal participants aged 55-70 (mean = 60.1) engaged in six weeks of rote learning, during which they learned 500 words per week every week (prose, poetry etc.). An extensive battery of memory tests was administered on three occasions, each six weeks apart. In addition, proton magnetic resonance spectroscopy (1H-MRS) was used to measure metabolite levels in seven voxels of interest (VOIs) (including hippocampus) before and after learning. RESULTS: Results indicate a facilitation of new learning that was evident six weeks after rote learning ceased. This facilitation occurred for verbal/episodic material only, and was mirrored by a metabolic change in left posterior hippocampus, specifically an increase in NAA/(Cr+Cho) ratio. CONCLUSION: Results suggest that repeated activation of memory structures facilitates anamnesis and may promote neuronal plasticity in the ageing brain, and that compliance is a key factor in such facilitation as the effect was confined to those who engaged fully with the training.
- Relationships among hippocampal volumetry, proton magnetic resonance spectroscopy, and verbal memory in temporal lobe epilepsy.
- Authors: Sawrie SM, Martin RC, Knowlton R, Faught E, Gilliam F, Kuzniecky R
- Issue date: 2001 Nov
- Synchronized brain activity during rehearsal and short-term memory disruption by irrelevant speech is affected by recall mode.
- Authors: Kopp F, Schröger E, Lipka S
- Issue date: 2006 Aug
- The 5-HT4 receptor levels in hippocampus correlates inversely with memory test performance in humans.
- Authors: Haahr ME, Fisher P, Holst K, Madsen K, Jensen CG, Marner L, Lehel S, Baaré W, Knudsen G, Hasselbalch S
- Issue date: 2013 Nov
- Brain activation on fMRI and verbal memory ability: functional neuroanatomic correlates of CVLT performance.
- Authors: Johnson SC, Saykin AJ, Flashman LA, McAllister TW, Sparling MB
- Issue date: 2001 Jan
- Hippocampal region-specific contributions to memory performance in normal elderly.
- Authors: Chen KH, Chuah LY, Sim SK, Chee MW
- Issue date: 2010 Apr