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Multi-species probiotic supplement enhances vagal nerve function - results of a randomized controlled trial in patients with depression and healthy controls.

dc.contributor.authorMörkl, Sabrina
dc.contributor.authorNarrath, Martin
dc.contributor.authorSchlotmann, Daria
dc.contributor.authorSallmutter, Marie-Therese
dc.contributor.authorPutz, Julia
dc.contributor.authorLang, Julia
dc.contributor.authorBrandstätter, Andreas
dc.contributor.authorPilz, Rene
dc.contributor.authorKarl Lackner, Helmut
dc.contributor.authorGoswami, Nandu
dc.contributor.authorSteuber, Bianca
dc.contributor.authorTatzer, Jasmin
dc.contributor.authorLackner, Sonja
dc.contributor.authorHolasek, Sandra
dc.contributor.authorPainold, Annamaria
dc.contributor.authorJauk, Emanuel
dc.contributor.authorWenninger, Julian
dc.contributor.authorHorvath, Angela
dc.contributor.authorSpicher, Nicolai
dc.contributor.authorBarth, Asmus
dc.contributor.authorButler, Mary I
dc.contributor.authorWagner-Skacel, Jolana
dc.date.accessioned2025-06-10T08:25:35Z
dc.date.available2025-06-10T08:25:35Z
dc.date.issued2025-04-29
dc.identifier.pmid40298641
dc.identifier.doi10.1080/19490976.2025.2492377
dc.identifier.urihttp://hdl.handle.net/10147/645243
dc.descriptionMajor depression (MD) significantly impacts individual well-being and society. The vagus nerve plays a pivotal role in the gut-brain axis, facilitating bidirectional communication between these systems. Recent meta-analyses suggest potential antidepressant effects of probiotics, although their mechanisms remain unclear. This study aimed to assess the impact of a multi-species probiotic (OMNi-BiOTiC® STRESS Repair) on vagus nerve function in 43 MD patients and 43 healthy controls (HC). Participants received either probiotics or placebo twice daily. Serum and stool samples were collected at baseline, 7 days, 28 days, and 3 months. Vagus nerve (VN) function was evaluated using 24-hour electrocardiography (ECG) for heart rate variability (HRV), alongside stool microbiome analysis via 16S rRNA sequencing. After 3 months, MD patients receiving probiotics demonstrated significantly improved morning VN function compared to HC. MD participants who were in the probiotic group showed a significant increase in Christensellales, particularly Akkermansia muciniphila along with improved sleep parameters (use of sleep medication, sleep latency) as measured by the Pittsburgh Sleep Quality Inventory (PSI). This study highlights potential physiological benefits of probiotics in MD, potentially mediated through VN stimulation. Understanding these mechanisms could lead to novel therapeutic approaches for MD management.en_US
dc.language.isoenen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectVagus nerveen_US
dc.subjectDEPRESSIONen_US
dc.subjectGUT MICROBIOMEen_US
dc.subjectheart rate variabilityen_US
dc.subjectprobioticen_US
dc.titleMulti-species probiotic supplement enhances vagal nerve function - results of a randomized controlled trial in patients with depression and healthy controls.en_US
dc.typeArticleen_US
dc.typeOtheren_US
dc.identifier.eissn1949-0984
dc.identifier.journalGut microbesen_US
dc.source.journaltitleGut microbes
dc.source.volume17
dc.source.issue1
dc.source.beginpage2492377
dc.source.endpage
refterms.dateFOA2025-06-10T08:25:38Z
dc.source.countryUnited States


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International