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A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos.

dc.contributor.authorRankin-Turner, Stephanie
dc.contributor.authorVader, Pieter
dc.contributor.authorO'Driscoll, Lorraine
dc.contributor.authorGiebel, Bernd
dc.contributor.authorHeaney, Liam M
dc.contributor.authorDavies, Owen G
dc.date.accessioned2025-01-31T12:14:36Z
dc.date.available2025-01-31T12:14:36Z
dc.date.issued2021-04-20
dc.identifier.pmid33862168
dc.identifier.doi10.1016/j.addr.2021.04.012
dc.identifier.urihttp://hdl.handle.net/10147/644132
dc.descriptionExtracellular vesicles (EVs) are complex nanoparticles required for the intercellular transfer of diverse biological cargoes. Unlike synthetic nanoparticles, EVs may provide a natural platform for the enhanced targeting and functional transfer of therapeutics across complex and often impenetrable biological boundaries (e.g. the blood-brain barrier or the matrix of densely organised tumours). Consequently, there is considerable interest in utilising EVs as advanced drug delivery systems for the treatment of a range of challenging pathologies. Within the past decade, efforts have focused on providing standard minimal requirements for conducting basic EV research. However, no standard reporting framework has been established governing the therapeutic loading of EVs for drug delivery applications. The purpose of this review is to critically evaluate progress in the field, providing an initial set of guidelines that can be applied as a benchmark to enhance reproducibility and increase the likelihood of translational outcomes.en_US
dc.language.isoenen_US
dc.rightsCopyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectDRUG DELIVERYen_US
dc.subjectefficiencyen_US
dc.subjectexosomesen_US
dc.subjectextracellular vesiclesen_US
dc.subjectguidelinesen_US
dc.subjectLoadingen_US
dc.subjectMicrovesiclesen_US
dc.titleA call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos.en_US
dc.typeArticleen_US
dc.identifier.eissn1872-8294
dc.identifier.journalAdvanced drug delivery reviewsen_US
dc.source.journaltitleAdvanced drug delivery reviews
dc.source.volume173
dc.source.beginpage479
dc.source.endpage491
refterms.dateFOA2025-01-31T12:14:38Z
dc.source.countryNetherlands


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Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
Except where otherwise noted, this item's license is described as Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.