Summary of SARS-CoV-2 virus variants in Ireland. Week 1 2025 (week ending 04/01/2025)

Health Protection Surveillance Centre (HPSC)

dc.contributor.author	Health Protection Surveillance Centre (HPSC)
dc.date.accessioned	2025-01-10T10:41:12Z
dc.date.available	2025-01-10T10:41:12Z
dc.date.issued	2025-01-06
dc.identifier.uri	http://hdl.handle.net/10147/643879
dc.description	Since December 2023, JN.1 sublineages have dominated circulating SARS-CoV-2 variants worldwide. To date, a number of JN.1 sublineages have arisen with various combinations of mutations that offer a competitive advantage such as the spike mutations F456L and R346T. The KP.3 variant, which is a WHO and ECDC Variant of Interest (VOI), and its sublineages are currently dominant globally and in Ireland. Since week 35 2024, the XEC variant (KS.1.1 and KP.3.3 recombinant, also a WHO and ECDC VOI) has steadily risen in prevalence in Ireland and globally.1,2 There is no evidence to date of an increase in clinical severity or reduction in vaccine effectiveness against severe disease among currently circulating variants3 • There have been 5,023 COVID-19 cases confirmed as infected with the JN.1 lineage and sublineages since week 40 2023 in Ireland. • JN.1 and its sublineages now predominate sequenced cases in Ireland and between weeks 45 and 49 2024 accounted for 52.7% of sequences. • KP.3 and its sublineages accounted for 41.9% of sequences between weeks 45 to 49 2024. This compares to 66.2% between weeks 40 to 44 2024. • The XEC lineage accounted for 46.7% of sequences between weeks 45 to 49 2024. This compares to 23.7% between weeks 40 to 44 2024. This report summarises all reported SARS-CoV-2 WGS data in Ireland. It focusses on data from 2024 and more recent weeks. Results since week 40 2023, and for the most recent five weeks, are shown in Figures 1a and 1b, 2a and 2b, 3a and 3b, Tables 1a and 1b and Table 2.	en_US
dc.language.iso	en	en_US
dc.publisher	Health Service Executive	en_US
dc.rights	Attribution 4.0 International	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	Epidemiology	en_US
dc.subject	public health	en_US
dc.subject	INFECTIOUS DISEASES	en_US
dc.subject	COVID-19	en_US
dc.subject	CORONAVIRUS	en_US
dc.subject	WHOLE GENOME SEQUENCING	en_US
dc.title	Summary of SARS-CoV-2 virus variants in Ireland. Week 1 2025 (week ending 04/01/2025)	en_US
dc.type	Report	en_US
dc.contributor.affiliation	Health Protection Surveillance Centre (HPSC)	en
refterms.dateFOA	2025-01-10T10:41:13Z