Low incidence of BRAF and NRAS mutations in a population with a high incidence of melanoma.

Neville, Grace; Marzario, Barbara; Shilling, David; Hand, Collette K; Heffron, Cynthia

dc.contributor.author	Neville, Grace
dc.contributor.author	Marzario, Barbara
dc.contributor.author	Shilling, David
dc.contributor.author	Hand, Collette K
dc.contributor.author	Heffron, Cynthia
dc.date.accessioned	2024-12-10T11:31:00Z
dc.date.available	2024-12-10T11:31:00Z
dc.date.issued	2024-01-06
dc.identifier.pmid	38183457
dc.identifier.doi	10.1007/s00428-023-03732-1
dc.identifier.uri	http://hdl.handle.net/10147/643674
dc.description	Reported rates of BRAF mutation in Irish cutaneous melanoma cohorts are lower than the reported international data. We aimed to assess the mutational status of a cohort of primary cutaneous melanomas and to correlate it with clinical follow-up data. A total of 92 cases of primary cutaneous melanoma diagnosed at a single institution in 2012 were analyzed. Regions containing common mutations in the BRAF, NRAS, KIT, and KRAS genes were investigated by PCR amplification followed by Sanger sequencing. Demographic details, tumor characteristics, and 10-year outcome data were also obtained. Ten cases with BRAF V600E mutations (11.6%) and five (5.49%) NRAS mutations (4 at Q61R, 1 at Q61K) were detected. No statistically significant differences were noted between groups for age, gender, depth of invasion, nodal status, or recurrence status (p ≥ 0.05). These findings suggest that the Irish population has a markedly lower incidence of BRAF and NRAS mutations in melanoma than those reported in other cohorts.	en_US
dc.language.iso	en	en_US
dc.rights	© 2024. The Author(s).
dc.rights	Attribution 4.0 International	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	braf mutation	en_US
dc.subject	NRAS mutation	en_US
dc.subject	MELANOMA	en_US
dc.title	Low incidence of BRAF and NRAS mutations in a population with a high incidence of melanoma.	en_US
dc.type	Article	en_US
dc.identifier.eissn	1432-2307
dc.identifier.journal	Virchows Archiv : an international journal of pathology	en_US
dc.source.journaltitle	Virchows Archiv : an international journal of pathology
dc.source.volume	484
dc.source.issue	3
dc.source.beginpage	475
dc.source.endpage	479
refterms.dateFOA	2024-12-10T11:31:02Z
dc.source.country	Germany