Bile acids, bioactive signalling molecules in interoceptive gut-to-brain communication.

Joyce, Susan A; O'Malley, Dervla

dc.contributor.author	Joyce, Susan A
dc.contributor.author	O'Malley, Dervla
dc.date.accessioned	2024-07-17T14:13:07Z
dc.date.available	2024-07-17T14:13:07Z
dc.date.issued	2022-04-30
dc.identifier.pmid	35413130
dc.identifier.doi	10.1113/JP281727
dc.identifier.uri	http://hdl.handle.net/10147/642289
dc.description	Aside from facilitating solubilisation and absorption of dietary lipids and lipid-soluble vitamins, amphipathic bile acids (BAs) also act as bioactive signalling molecules. A plethora of conjugated or unconjugated primary and bacterially modified secondary BA moieties have been identified, with significant divergence between species. These molecules are excreted into the external environment of the intestinal lumen, yet nuclear and membrane receptors that are sensitive to BAs are expressed internally in the liver, intestinal and neural tissues, amongst others. The diversity of BAs and receptors underpins the multitude of distinct bioactive functions attributed to BAs, but also hampers elucidation of the physiological mechanisms underpinning these actions. In this Topical Review, we have considered the potential of BAs as cross-barrier signalling molecules that contribute to interoceptive pathways informing the central nervous system of environmental changes in the gut lumen. Activation of BAs on FGF19 -secreting enterocytes, enteroendocrine cells coupled to sensory nerves or intestinal immune cells would facilitate indirect signalling, whereas direct activation of BA receptors in the brain is likely to occur primarily under pathophysiological conditions when concentrations of BAs are elevated.	en_US
dc.language.iso	en	en_US
dc.rights	© 2022 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 International	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	FXR	en_US
dc.subject	TGR5	en_US
dc.subject	bile acid	en_US
dc.subject	brain-gut axis	en_US
dc.subject	MICROBIOTA	en_US
dc.subject	pathophysiology	en_US
dc.title	Bile acids, bioactive signalling molecules in interoceptive gut-to-brain communication.	en_US
dc.type	Article	en_US
dc.type	Other	en_US
dc.identifier.eissn	1469-7793
dc.identifier.journal	The Journal of physiology	en_US
dc.source.journaltitle	The Journal of physiology
dc.source.volume	600
dc.source.issue	11
dc.source.beginpage	2565
dc.source.endpage	2578
refterms.dateFOA	2024-07-17T14:13:09Z
dc.source.country	England