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DOACs or VKAs or LMWH - What is the optimal regimen for cancer-associated venous thromboembolism? A systematic review and meta-analysis.

dc.contributor.authorYamani, Naser
dc.contributor.authorUnzek, Samuel
dc.contributor.authorAlmas, Talal
dc.contributor.authorMusheer, Adeena
dc.contributor.authorEjaz, Arooba
dc.contributor.authorParacha, Anousheh Awais
dc.contributor.authorShahid, Izza
dc.contributor.authorMookadam, Farouk
dc.date.accessioned2024-07-15T09:40:22Z
dc.date.available2024-07-15T09:40:22Z
dc.date.issued2022-06-09
dc.identifier.issn2049-0801
dc.identifier.pmid35860059
dc.identifier.doi10.1016/j.amsu.2022.103925
dc.identifier.urihttp://hdl.handle.net/10147/642175
dc.descriptionA total of 8 randomized controlled trials (RCTs) enrolling almost 7000 patients were included. Direct oral anticoagulants significantly reduced VTE Recurrence in cancer patients when compared to patients treated with LMWH or VKAs (Hazard ratio [HR] 0.62, 95% confidence interval [CI] 0.46-0.83; P = 0.002; I2 = 26%). There were no statistically significant differences for major bleeding (HR 0.86, 95% confidence interval [CI] 0.56-1.33; P = 0.50; I2 = 34%), clinically relevant non-major bleeding (HR 1.23, 95% confidence interval [CI] 0.79-1.91; P = 0.35; I2 = 66%), pulmonary embolism (HR 0.71, 95% confidence interval [CI] 0.47-1.06; P = 0.10; I2 = 7%), and all-cause mortality (HR 0.98, 95% confidence interval [CI] 0.86-1.12; P = 0.78; I2 = 1%), between DOACs and LMWH.en_US
dc.language.isoenen_US
dc.rights© 2022 The Author(s).
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAnticoagulanten_US
dc.subjectBleedingen_US
dc.subjectCanceren_US
dc.subjectEmbolismen_US
dc.subjectMORTALITYen_US
dc.titleDOACs or VKAs or LMWH - What is the optimal regimen for cancer-associated venous thromboembolism? A systematic review and meta-analysis.en_US
dc.typeArticleen_US
dc.typeOtheren_US
dc.identifier.journalAnnals of medicine and surgery (2012)en_US
dc.source.journaltitleAnnals of medicine and surgery (2012)
dc.source.volume79
dc.source.beginpage103925
dc.source.endpage
refterms.dateFOA2024-07-15T09:40:24Z
dc.source.countryEngland


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