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Improved gut microbiome recovery following drug therapy is linked to abundance and replication of probiotic strains.

dc.contributor.authorFitzGerald, Jamie
dc.contributor.authorPatel, Shriram
dc.contributor.authorEckenberger, Julia
dc.contributor.authorGuillemard, Eric
dc.contributor.authorVeiga, Patrick
dc.contributor.authorSchäfer, Florent
dc.contributor.authorWalter, Jens
dc.contributor.authorClaesson, Marcus J
dc.contributor.authorDerrien, Muriel
dc.date.accessioned2024-07-10T15:55:43Z
dc.date.available2024-07-10T15:55:43Z
dc.identifier.pmid35916669
dc.identifier.doi10.1080/19490976.2022.2094664
dc.identifier.urihttp://hdl.handle.net/10147/642072
dc.descriptionProbiotics have been used for decades to alleviate the negative side-effects of oral antibiotics, but our mechanistic understanding on how they work is so far incomplete. Here, we performed a metagenomic analysis of the fecal microbiota in participants who underwent a 14-d Helicobacter pylori eradication therapy with or without consumption of a multi-strain probiotic intervention (L. paracasei CNCM I-1518, L. paracasei CNCM I-3689, L. rhamnosus CNCM I-3690, and four yogurt strains) in a randomized, double-blinded, controlled clinical trial. Using a strain-level analysis for detection and metagenomic determination of replication rate, ingested strains were detected and replicated transiently in fecal samples and in the gut during and following antibiotic administration. Consumption of the fermented milk product led to a significant, although modest, improvement in the recovery of microbiota composition. Stratification of participants into two groups based on the degree to which their microbiome recovered showed i) a higher fecal abundance of the probiotic L. paracasei and L. rhamnosus strains and ii) an elevated replication rate of one strain (L. paracasei CNCMI-1518) in the recovery group. Collectively, our findings show a small but measurable benefit of a fermented milk product on microbiome recovery after antibiotics, which was linked to the detection and replication of specific probiotic strains. Such functional insight can form the basis for the development of probiotic-based intervention aimed to protect gut microbiome from drug treatments.en_US
dc.language.isoenen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectANTIBIOTICSen_US
dc.subjectL. paracasei CNCM I-1518en_US
dc.subjectfermented milk producten_US
dc.subjectgut microbiome recoveryen_US
dc.subjectprobioticsen_US
dc.subjectreplicationen_US
dc.titleImproved gut microbiome recovery following drug therapy is linked to abundance and replication of probiotic strains.en_US
dc.typeArticleen_US
dc.typeOtheren_US
dc.identifier.eissn1949-0984
dc.identifier.journalGut microbesen_US
dc.source.journaltitleGut microbes
dc.source.volume14
dc.source.issue1
dc.source.beginpage2094664
dc.source.endpage
refterms.dateFOA2024-07-10T15:55:45Z
dc.source.countryUnited States


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International