Risk stratification of sudden cardiac death in asymptomatic female Brugada syndrome patients: A literature review.

Leung, Keith Sai Kit; Radford, Danny; Huang, Helen; Lakhani, Ishan; Li, Christien Ka Hou; Hothi, Sandeep Singh; Wai, Abraham Ka Chung; Liu, Tong; Tse, Gary; Lee, Sharen

dc.contributor.author	Leung, Keith Sai Kit
dc.contributor.author	Radford, Danny
dc.contributor.author	Huang, Helen
dc.contributor.author	Lakhani, Ishan
dc.contributor.author	Li, Christien Ka Hou
dc.contributor.author	Hothi, Sandeep Singh
dc.contributor.author	Wai, Abraham Ka Chung
dc.contributor.author	Liu, Tong
dc.contributor.author	Tse, Gary
dc.contributor.author	Lee, Sharen
dc.date.accessioned	2024-06-27T09:23:37Z
dc.date.available	2024-06-27T09:23:37Z
dc.date.issued	2023-01-11
dc.identifier.pmid	36628595
dc.identifier.doi	10.1111/anec.13030
dc.identifier.uri	http://hdl.handle.net/10147/641794
dc.description	Background and Objectives Risk stratification in Brugada syndrome remains a difficult problem. Given the male predominance of this disease and their elevated risks of arrhythmic events, affected females have received less attention. It is widely known that symptomatic patients are at increased risk of sudden cardiac death (SCD) than asymptomatic patients, while this might be true in the male population; recent studies have shown that this association might not be significant in females. Over the past few decades, numerous markers involving clinical symptoms, electrocardiographic (ECG) indices, and genetic tests have been explored, with several risk‐scoring models developed so far. The objective of this study is to review the current evidence of clinical and ECG markers as well as risk scores on asymptomatic females with Brugada syndrome. Findings Gender differences in ECG markers, the yield of genetic findings, and the applicability of risk scores are highlighted. Conclusions Various clinical, electrocardiographic, and genetic risk factors are available for assessing SCD risk amongst asymptomatic female BrS patients. However, due to the significant gender discrepancy in BrS, the SCD risk amongst females is often underestimated, and there is a lack of research on female‐specific risk factors and multiparametric risk scores. Therefore, multinational studies pooling female BrS patients are needed for the development of a gender‐specific risk stratification approach amongst asymptomatic BrS patients.	en_US
dc.language.iso	en	en_US
dc.rights	© 2023 The Authors. Annals of Noninvasive Electrocardiology published by Wiley Periodicals LLC.
dc.rights	Attribution 4.0 International	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	brugada syndrome	en_US
dc.subject	gender difference	en_US
dc.subject	risk stratification	en_US
dc.subject	sudden cardiac death	en_US
dc.title	Risk stratification of sudden cardiac death in asymptomatic female Brugada syndrome patients: A literature review.	en_US
dc.type	Article	en_US
dc.type	Other	en_US
dc.identifier.eissn	1542-474X
dc.identifier.journal	Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc	en_US
dc.source.journaltitle	Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
dc.source.volume	28
dc.source.issue	2
dc.source.beginpage	e13030
dc.source.endpage
refterms.dateFOA	2024-06-27T09:23:40Z
dc.source.country	United States