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Rhinovirus-induced epithelial RIG-I inflammasome suppresses antiviral immunity and promotes inflammation in asthma and COVID-19.

dc.contributor.authorStocker, Nino
dc.contributor.authorDreher, Anita
dc.contributor.authorWawrzyniak, Paulina
dc.contributor.authorRodriguez-Coira, Juan
dc.contributor.authorZhakparov, Damir
dc.contributor.authorHuang, Mengting
dc.contributor.authorJutel, Marek
dc.contributor.authorKebadze, Tatiana
dc.contributor.authorJackson, David J
dc.contributor.authorEdwards, Michael R
dc.contributor.authorRadzikowska, Urszula
dc.contributor.authorEljaszewicz, Andrzej
dc.contributor.authorTan, Ge
dc.contributor.authorHeider, Anja
dc.contributor.authorWestermann, Patrick
dc.contributor.authorSteiner, Silvio
dc.contributor.authorRückert, Beate
dc.contributor.authorJakiela, Bogdan
dc.contributor.authorSanak, Marek
dc.contributor.authorO'Mahony, Liam
dc.contributor.authorMoniuszko, Marcin
dc.contributor.authorThiel, Volker
dc.contributor.authorSokolowska, Milena
dc.contributor.authorJohnston, Sebastian
dc.contributor.authorAkdis, Cezmi
dc.date.accessioned2023-11-06T15:29:22Z
dc.date.available2023-11-06T15:29:22Z
dc.date.issued22/04/2023
dc.identifier.pmid37087523
dc.identifier.doi10.1038/s41467-023-37470-4
dc.identifier.urihttp://hdl.handle.net/10147/638279
dc.descriptionRhinoviruses and allergens, such as house dust mite are major agents responsible for asthma exacerbations. The influence of pre-existing airway inflammation on the infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is largely unknown. We analyse mechanisms of response to viral infection in experimental in vivo rhinovirus infection in healthy controls and patients with asthma, and in in vitro experiments with house dust mite, rhinovirus and SARS-CoV-2 in human primary airway epithelium. Here, we show that rhinovirus infection in patients with asthma leads to an excessive RIG-I inflammasome activation, which diminishes its accessibility for type I/III interferon responses, leading to their early functional impairment, delayed resolution, prolonged viral clearance and unresolved inflammation in vitro and in vivo. Pre-exposure to house dust mite augments this phenomenon by inflammasome priming and auxiliary inhibition of early type I/III interferon responses. Prior infection with rhinovirus followed by SARS-CoV-2 infection augments RIG-I inflammasome activation and epithelial inflammation. Timely inhibition of the epithelial RIG-I inflammasome may lead to more efficient viral clearance and lower the burden of rhinovirus and SARS-CoV-2 infections.en_US
dc.language.isoenen_US
dc.subjectrespiratory epithelial cellsen_US
dc.subjectCOVID‐19en_US
dc.subjectALLERGIESen_US
dc.subjectairway epithelial cellsen_US
dc.titleRhinovirus-induced epithelial RIG-I inflammasome suppresses antiviral immunity and promotes inflammation in asthma and COVID-19.en_US
dc.typeArticleen_US
dc.typeOtheren_US
dc.identifier.eissn2041-1723
dc.identifier.journalNature communicationsen_US
dc.identifier.pmcidPMC10122208
dc.source.journaltitleNature communications
dc.source.volume14
dc.source.issue1
dc.source.beginpage2329
refterms.dateFOA2023-11-06T15:29:23Z
dc.source.countryUnited Kingdom
dc.source.countryEngland


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