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JournalRadiology case reports
PubMed Central IDPMC8924534
AbstractVoriconazole is a broad-spectrum triazole antifungal used to treat invasive fungal infections. It is commonly used prophylactically in immunocompromized patient cohorts, including transplant recipients. Diffuse periostitis is a very rare complication of chronic voriconazole use. It is associated with diffuse bone pain, elevated serum alkaline phosphatase and fluorine levels. Characteristic imaging findings include periosteal thickening with a dense, nodular, irregular and often bilateral pattern. We describe the case of a 71-year-old female who presented with multifocal bone pain six years following double lung transplantation. Her post transplantation course had been complicated by a life threatening episode of sepsis secondary to Scedosporium apiospermum, a rare invasive fungal infection following which lifelong prophylaxis with oral Voriconazole was commenced. We discuss the characteristic clinical and imaging manifestations of this rare condition.
- Voriconazole-Induced Diffuse Periostitis.
- Authors: Stefan S, Altork N, Alzedaneen Y, Whitlatch H, Munir KM
- Issue date: 2022 Sep-Oct
- Voriconazole-induced periostitis.
- Authors: Fernández Ávila DC, Diehl M, Degrave AM, Buttazzoni M, Pereira T, Aguirre MA, Basquiera AL, Scolnik M
- Issue date: 2021 Apr 19
- Spectrum of voriconazole-associated periostitis in clinical characteristics, diagnosis and management.
- Authors: Li Z, Wu C, Wang C, Deng Z
- Issue date: 2022 Oct
- Periostitis secondary to prolonged voriconazole therapy in a lung transplant recipient.
- Authors: Lustenberger DP, Granata JD, Scharschmidt TJ
- Issue date: 2011 Nov 9
- Periostitis secondary to prolonged voriconazole therapy in lung transplant recipients.
- Authors: Wang TF, Wang T, Altman R, Eshaghian P, Lynch JP 3rd, Ross DJ, Belperio JA, Weigt SS, Saggar R, Gregson A, Kubak B, Saggar R
- Issue date: 2009 Dec