Show simple item record

dc.contributor.authorSchuurmans, Isabel K
dc.contributor.authorRadjabzadeh, Djawad
dc.contributor.authorTiemeier, Henning
dc.contributor.authorUitterlinden, André G
dc.contributor.authorHillegers, Manon
dc.contributor.authorJaddoe, Vincent W V
dc.contributor.authorDuijts, Liesbeth
dc.contributor.authorMoll, Henriette
dc.contributor.authorRivadeneira, Fernando
dc.contributor.authorMedina-Gomez, Carolina
dc.contributor.authorJansen, Pauline W
dc.contributor.authorCecil, Charlotte A M
dc.contributor.authorKraaij, Robert
dc.contributor.authorDinan, Timothy
dc.date.accessioned2023-03-15T12:55:57Z
dc.date.available2023-03-15T12:55:57Z
dc.date.issued2022-12-06
dc.identifier.pmid36494050
dc.identifier.doi10.1016/j.bbi.2022.12.006
dc.identifier.urihttp://hdl.handle.net/10147/635140
dc.descriptionThe link between the gut microbiome and the brain has gained increasing scientific and public interest for its potential to explain psychiatric risk. While differences in gut microbiome composition have been associated with several mental health problems, evidence to date has been largely based on animal models and human studies with modest sample sizes. In this cross-sectional study in 1,784 ten-year-old children from the multi-ethnic, population-based Generation R Study, we aimed to characterize associations of the gut microbiome with child mental health problems. Gut microbiome was assessed from stool samples using 16S rRNA sequencing. We focused on overall psychiatric symptoms as well as with specific domains of emotional and behavioral problems, assessed via the maternally rated Child Behavior Checklist. While we observed lower gut microbiome diversity in relation to higher overall and specific mental health problems, associations were not significant. Likewise, we did not identify any taxonomic feature associated with mental health problems after multiple testing correction, although suggestive findings indicated depletion of genera previously associated with psychiatric disorders, including Hungatella, Anaerotruncus and Oscillospiraceae. The identified compositional abundance differences were found to be similar across all mental health problems. Finally, we did not find significant enrichment for specific microbial functions in relation to mental health problems. In conclusion, based on the largest sample examined to date, we do not find clear evidence of associations between gut microbiome diversity, taxonomies or functions and mental health problems in the general pediatric population. In future, the use of longitudinal designs with repeated measurements of microbiome and psychiatric outcomes will be critical to identify whether and when associations between the gut microbiome and mental health emerge across development and into adulthood.en_US
dc.language.isoenen_US
dc.rightsCopyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
dc.subjectChild mental healthen_US
dc.subjectepidemiologyen_US
dc.subjectGut-brain-axisen_US
dc.subjectMICROBIOMEen_US
dc.subjectPopulation-baseden_US
dc.subjectPSYCHIATRYen_US
dc.subjectChild mental healthen_US
dc.titleThe gut microbiome and child mental health: A population-based study.en_US
dc.typeArticleen_US
dc.identifier.eissn1090-2139
dc.identifier.journalBrain, behavior, and immunityen_US
dc.identifier.pmcidPMC7614161
dc.source.journaltitleBrain, behavior, and immunity
dc.source.volume108
dc.source.beginpage188
dc.source.endpage196
refterms.dateFOA2023-03-15T12:55:59Z
dc.source.countryInternational
dc.source.countryNetherlands


Files in this item

Thumbnail
Name:
Publisher version
Thumbnail
Name:
EMS164585.pdf
Size:
1.197Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record