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dc.contributor.authorOwens, Susan C
dc.contributor.authorPerera, Rasika
dc.contributor.authorEngelen, Marielle P K J
dc.contributor.authorDeutz, Nicolaas E P
dc.contributor.authorSenarathne, Udara
dc.contributor.authorIndika, Neluwa-Liyanage
dc.contributor.authorFrye, Richard
dc.contributor.authorGrabrucker, Andreas
dc.contributor.authorRossignol, Daniel
dc.date.accessioned2023-03-15T12:39:19Z
dc.date.available2023-03-15T12:39:19Z
dc.date.issued2023-01-29
dc.identifier.issn2075-4426
dc.identifier.pmid36836486
dc.identifier.doi10.3390/jpm13020252
dc.identifier.urihttp://hdl.handle.net/10147/635135
dc.descriptionChildren with autism spectrum disorder may exhibit nutritional deficiencies due to reduced intake, genetic variants, autoantibodies interfering with vitamin transport, and the accumulation of toxic compounds that consume vitamins. Importantly, vitamins and metal ions are essential for several metabolic pathways and for neurotransmitter functioning. The therapeutic benefits of supplementing vitamins, minerals (Zinc, Magnesium, Molybdenum, and Selenium), and other cofactors (coenzyme Q10, alpha-lipoic acid, and tetrahydrobiopterin) are mediated through their cofactor as well as non-cofactor functions. Interestingly, some vitamins can be safely administered at levels far above the dose typically used to correct the deficiency and exert effects beyond their functional role as enzyme cofactors. Moreover, the interrelationships between these nutrients can be leveraged to obtain synergistic effects using combinations. The present review discusses the current evidence for using vitamins, minerals, and cofactors in autism spectrum disorder, the rationale behind their use, and the prospects for future use.en_US
dc.language.isoenen_US
dc.subjectAUTISMen_US
dc.subjectcofactorsen_US
dc.subjectmicronutrientsen_US
dc.subjectMINERALSen_US
dc.subjectNUTRITIONen_US
dc.subjectsupplementsen_US
dc.subjectvitaminsen_US
dc.titleThe Rationale for Vitamin, Mineral, and Cofactor Treatment in the Precision Medical Care of Autism Spectrum Disorder.en_US
dc.typeArticleen_US
dc.identifier.journalJournal of personalized medicineen_US
dc.identifier.pmcidPMC9964499
dc.source.journaltitleJournal of personalized medicine
dc.source.volume13
dc.source.issue2
refterms.dateFOA2023-03-15T12:39:21Z
dc.source.countrySwitzerland


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