• Login
    View Item 
    •   Home
    • Hospital Research
    • Connacht
    • Galway University Hospitals
    • View Item
    •   Home
    • Hospital Research
    • Connacht
    • Galway University Hospitals
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    4943
    UlsterS
    4943
    Connacht
    1618
    Munster
    58
    Leinster
    454

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideNational Health Library & Knowledge ServiceGuide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementORCID Unique identifiers for ResearchersHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Perioperative Levosimendan Infusion in Patients With End-Stage Heart Failure Undergoing Left Ventricular Assist Device Implantation.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    fcvm-09-888136.pdf
    Size:
    730.2Kb
    Format:
    PDF
    Download
    Authors
    Abdelshafy, Mahmoud
    Elsherbini, Hagar
    Elkoumy, Ahmed
    Simpkin, Andrew J
    Elzomor, Hesham
    Caliskan, Kadir
    Soliman, Osama
    Issue Date
    2022-04-28
    Keywords
    LVAD
    HEART FAILURE
    inotropes
    levosimendan
    mechanical circularity support
    right-sided heart failure
    
    Metadata
    Show full item record
    Journal
    Frontiers in cardiovascular medicine
    URI
    http://hdl.handle.net/10147/634351
    DOI
    10.3389/fcvm.2022.888136
    PubMed ID
    35571194
    Abstract
    Left ventricular assist device (LVAD) therapy has been instrumental in saving lives of patients with end-stage heart failure (HF). Recent generation devices have short-to-mid-term survival rates close to heart transplantation. Unfortunately, up to 1 in 4 patients develop a life-threatening right-sided HF (RHF) early post LVAD implantation, with high morbidity and mortality rate, necessitating prolonged ICU stay, prolonged inotropic support, and implantation of a right-ventricular assist device. Pre-operative optimization of HF therapy could help in prevention, and/or mitigation of RHF. Levosimendan (LEVO) is a non-conventional inotropic agent that works by amplifying calcium sensitivity of troponin C in cardiac myocytes, without increasing the intra-cellular calcium or exacerbating ischemia. LEVO acts as an inodilator, which reduces the cardiac pre-, and after-load. LEVO administration is associated with hemodynamic improvements. Despite decades long of the use of LVAD and more than two decades of the use of LEVO for HF, the literature on LEVO use in LVAD is very limited. In this paper, we sought to conduct a systematic review to synthesize evidence related to the use of LEVO for the mitigation and/or prevention of RHF in patients undergoing LVAD implantation.
    Item Type
    Article
    Language
    en
    ISSN
    2297-055X
    ae974a485f413a2113503eed53cd6c53
    10.3389/fcvm.2022.888136
    Scopus Count
    Collections
    Galway University Hospitals

    entitlement

    Related articles

    • Efficacy of levosimendan infusion in patients undergoing a left ventricular assist device implant in a propensity score matched analysis of the EUROMACS registry-the Euro LEVO-LVAD study.
    • Authors: Abdelshafy M, Caliskan K, Simpkin AJ, Elkoumy A, Kimman JR, Elsherbini H, Elzomor H, de By TMMH, Gollmann-Tepeköylü C, Berchtold-Herz M, Loforte A, Reineke D, Schoenrath F, Paluszkiewicz L, Gummert J, Mohacsi P, Meyns B, Soliman O
    • Issue date: 2023 May 2
    • Preoperative Levosimendan therapy reduces postoperative right ventricular failure in patients undergoing left ventricular assist device implantation.
    • Authors: Sugimura Y, Kalampokas N, Arikan M, Rellecke P, Dalyanoglu H, Tudorache I, Westenfeld R, Boeken U, Lichtenberg A, Akhyari P, Aubin H
    • Issue date: 2023 Jan 9
    • Derivation and Validation of a Novel Right-Sided Heart Failure Model After Implantation of Continuous Flow Left Ventricular Assist Devices: The EUROMACS (European Registry for Patients with Mechanical Circulatory Support) Right-Sided Heart Failure Risk Score.
    • Authors: Soliman OII, Akin S, Muslem R, Boersma E, Manintveld OC, Krabatsch T, Gummert JF, de By TMMH, Bogers AJJC, Zijlstra F, Mohacsi P, Caliskan K, EUROMACS Investigators
    • Issue date: 2018 Feb 27
    • Right heart failure after left ventricular assist device implantation in patients with chronic congestive heart failure.
    • Authors: Dang NC, Topkara VK, Mercando M, Kay J, Kruger KH, Aboodi MS, Oz MC, Naka Y
    • Issue date: 2006 Jan
    • Right heart failure and "failure to thrive" after left ventricular assist device: clinical predictors and outcomes.
    • Authors: Baumwol J, Macdonald PS, Keogh AM, Kotlyar E, Spratt P, Jansz P, Hayward CS
    • Issue date: 2011 Aug
    Health Library Ireland | Health Service Executive | Jervis House, Jervis Street | Republic of Ireland | Eircode: D01 W596
    lenus@hse.ie | Tel: +353-1-7786275
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.