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    Human Monocyte Subset Distinctions and Function: Insights From Gene Expression Analysis.

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    Authors
    Cormican, Sarah
    Griffin, Matthew D
    Issue Date
    2020-06-04
    Keywords
    flow cytometry
    gene expression
    immune response
    inflammation
    microarray
    monocyte subsets
    monocytes
    next generation sequencing
    
    Metadata
    Show full item record
    Journal
    Frontiers in immunology
    URI
    http://hdl.handle.net/10147/631908
    DOI
    10.3389/fimmu.2020.01070
    PubMed ID
    32582174
    Abstract
    Monocytes are a highly plastic innate immune cell population that displays significant heterogeneity within the circulation. Distinct patterns of surface marker expression have become accepted as a basis for distinguishing three monocyte subsets in humans. These phenotypic subsets, termed classical, intermediate and nonclassical, have also been demonstrated to differ in regard to their functional properties and disease associations when studied in vitro and in vivo. Nonetheless, for the intermediate monocyte subset in particular, functional experiments have yielded conflicting results and some studies point to further levels of heterogeneity. Developments in genetic sequencing technology have provided opportunities to more comprehensively explore the phenotypic and functional differences among conventionally-recognized immune cell subtypes as well as the potential to identify novel subpopulations. In this review, we summarize the transcriptomic evidence in support of the existence of three separate monocyte subsets. We also critically evaluate the insights into subset functional distinctions that have been garnered from monocyte gene expression analysis and the potential utility of such studies to unravel subset-specific functional changes which arise in disease states.
    Item Type
    Article
    Other
    Language
    en
    EISSN
    1664-3224
    ae974a485f413a2113503eed53cd6c53
    10.3389/fimmu.2020.01070
    Scopus Count
    Collections
    Galway University Hospitals

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