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    Opportunities to Target T Cell Trafficking in Pediatric Inflammatory Bowel Disease.

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    Authors
    Giannoudaki, Eirini
    Gargan, Siobhan
    Hussey, Seamus
    Long, Aideen
    Walsh, Patrick T
    Issue Date
    2021-03-18
    Keywords
    CROHN'S DISEASE
    T cell trafficking
    infiltration
    INFLAMMATORY BOWEL DISEASE
    pediatric
    ulcerative colitis
    
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    Journal
    Frontiers in pediatrics
    URI
    http://hdl.handle.net/10147/631775
    DOI
    10.3389/fped.2021.640497
    PubMed ID
    33816403
    Abstract
    T cell subsets are considered central orchestrators of inflammation and homeostasis in the intestine and are established targets for the treatment of inflammatory bowel disease. While approaches aimed at the neutralization of T cell effector cytokines have provided significant benefits for pediatric and adult patients, more recent strategies aimed at inhibiting the infiltration of pathogenic T cell subsets have also emerged. In this review, we describe current knowledge surrounding the function of T cell subsets in pediatric inflammatory bowel disease and outline approaches aimed at targeting T cell trafficking to the intestine which may represent a new treatment option for pediatric inflammatory bowel disease.
    Item Type
    Article
    Language
    en
    ISSN
    2296-2360
    ae974a485f413a2113503eed53cd6c53
    10.3389/fped.2021.640497
    Scopus Count
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    Children's Health Ireland (CHI) at Crumlin

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