Opportunities to Target T Cell Trafficking in Pediatric Inflammatory Bowel Disease.
Issue Date
2021-03-18Keywords
CROHN'S DISEASET cell trafficking
infiltration
INFLAMMATORY BOWEL DISEASE
pediatric
ulcerative colitis
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Frontiers in pediatricsDOI
10.3389/fped.2021.640497PubMed ID
33816403Abstract
T cell subsets are considered central orchestrators of inflammation and homeostasis in the intestine and are established targets for the treatment of inflammatory bowel disease. While approaches aimed at the neutralization of T cell effector cytokines have provided significant benefits for pediatric and adult patients, more recent strategies aimed at inhibiting the infiltration of pathogenic T cell subsets have also emerged. In this review, we describe current knowledge surrounding the function of T cell subsets in pediatric inflammatory bowel disease and outline approaches aimed at targeting T cell trafficking to the intestine which may represent a new treatment option for pediatric inflammatory bowel disease.Item Type
ArticleLanguage
enISSN
2296-2360ae974a485f413a2113503eed53cd6c53
10.3389/fped.2021.640497
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