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dc.contributor.authorToledano, Manuel
dc.contributor.authorVallecillo-Rivas, Marta
dc.contributor.authorOsorio, María T
dc.contributor.authorMuñoz-Soto, Esther
dc.contributor.authorToledano-Osorio, Manuel
dc.contributor.authorVallecillo, Cristina
dc.contributor.authorToledano, Raquel
dc.contributor.authorLynch, Christopher D
dc.contributor.authorSerrera-Figallo, María-Angeles
dc.contributor.authorOsorio, Raquel
dc.date.accessioned2022-02-11T17:29:41Z
dc.date.available2022-02-11T17:29:41Z
dc.date.issued2021-05-29
dc.identifier.pmid34072433
dc.identifier.doi10.3390/polym13111797
dc.identifier.urihttp://hdl.handle.net/10147/631419
dc.description.abstractBarrier membranes are employed in guided bone regeneration (GBR) to facilitate bone in-growth. A bioactive and biomimetic Zn-doped membrane with the ability to participate in bone healing and regeneration is necessary. The aim of the present study is to state the effect of doping the membranes for GBR with zinc compounds in the improvement of bone regeneration. A literature search was conducted using electronic databases, such as PubMed, MEDLINE, DIMDI, Embase, Scopus and Web of Science. A narrative exploratory review was undertaken, focusing on the antibacterial effects, physicochemical and biological properties of Zn-loaded membranes. Bioactivity, bone formation and cytotoxicity were analyzed. Microstructure and mechanical properties of these membranes were also determined. Zn-doped membranes have inhibited in vivo and in vitro bacterial colonization. Zn-alloy and Zn-doped membranes attained good biocompatibility and were found to be non-toxic to cells. The Zn-doped matrices showed feasible mechanical properties, such as flexibility, strength, complex modulus and tan delta. Zn incorporation in polymeric membranes provided the highest regenerative efficiency for bone healing in experimental animals, potentiating osteogenesis, angiogenesis, biological activity and a balanced remodeling. Zn-loaded membranes doped with SiO2 nanoparticles have performed as bioactive modulators provoking an M2 macrophage increase and are a potential biomaterial for promoting bone repair. Zn-doped membranes have promoted pro-healing phenotypes.en_US
dc.language.isoenen_US
dc.subjectantibacterialen_US
dc.subjectbioactivityen_US
dc.subjectCYTOTOXICITYen_US
dc.subjectguided bone regenerationen_US
dc.subjectmechanicalen_US
dc.subjectmembranesen_US
dc.subjectmicroscopyen_US
dc.subjectzincen_US
dc.titleZn-Containing Membranes for Guided Bone Regeneration in Dentistry.en_US
dc.typeArticleen_US
dc.identifier.eissn2073-4360
dc.identifier.journalPolymersen_US
dc.description.peer-reviewpeer-reviewen_US
dc.source.journaltitlePolymers
dc.source.volume13
dc.source.issue11
refterms.dateFOA2022-02-11T17:29:41Z
dc.source.countrySwitzerland


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