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    Testicular swelling leading to a diagnosis of adrenocortical carcinoma - co-incidence or causation?

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    Name:
    [20520573 - Endocrinology, ...
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    Authors
    Batool, Maria
    Fennell, David
    Slattery, David
    Leen, Eamon
    Cormican, Liam
    Sreenan, Seamus
    H McDermott, John
    Issue Date
    2021-06-01
    Keywords
    ADRENOCORITCAL CARCINOMA
    SARCOIDOSIS
    
    Metadata
    Show full item record
    Journal
    Endocrinology, diabetes & metabolism case reports
    URI
    http://hdl.handle.net/10147/631340
    DOI
    10.1530/EDM-20-0177
    PubMed ID
    34156349
    Abstract
    Summary: Adrenocortical carcinoma (ACC) is a rare malignancy with an incidence of 0.7-2.0 cases/million/year. A majority of patients present with steroid hormone excess or abdominal mass effects, and in 15% of patients ACC is discovered incidentally. We present a case of 30-year-old otherwise asymptomatic Caucasian male who presented with a testicular swelling. Subsequent imaging and investigations revealed disseminated sarcoidosis and an 11 cm adrenal lesion. An adrenalectomy was performed. Histological examination of the resected specimen confirmed an ACC and also demonstrated a thin rim of adrenal tissue containing non-caseating granulomas, consistent with adrenal sarcoid. Learning points: This case highlights an unusual presentation of two uncommon diseases. This case also highlights how separate and potentially unrelated disease processes may occur concomitantly and the importance, therefore, of keeping an open mind when dealing with unusual diagnostic findings. We also hypothesize a potential link between the ACC and sarcoidosis in our patient.
    Item Type
    Article
    Language
    en
    ISSN
    2052-0573
    ae974a485f413a2113503eed53cd6c53
    10.1530/EDM-20-0177
    Scopus Count
    Collections
    Connolly Hospital

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