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dc.contributor.authorMurphy, Claire A
dc.contributor.authorO'Reilly, Daniel P
dc.contributor.authorEdebiri, Osasere
dc.contributor.authorWeiss, Luisa
dc.contributor.authorCullivan, Sarah
dc.contributor.authorEL-Khuffash, Afif
dc.contributor.authorDoyle, Emma
dc.contributor.authorDonnelly, Jennifer C
dc.contributor.authorMalone, Fergal D
dc.contributor.authorFerguson, Wendy
dc.contributor.authorDrew, Richard J
dc.contributor.authorO'Loughlin, John
dc.contributor.authorNeary, Elaine
dc.contributor.authorMaguire, Patricia B
dc.contributor.authorKevane, Barry
dc.contributor.authorNíAinle, Fionnuala
dc.contributor.authorMcCallion, Naomi
dc.date.accessioned2021-11-29T16:38:45Z
dc.date.available2021-11-29T16:38:45Z
dc.date.issued2021-09-21
dc.identifier.pmid34601263
dc.identifier.doi10.1016/j.ejogrb.2021.09.019
dc.identifier.urihttp://hdl.handle.net/10147/630713
dc.description.abstractObjective: The aim of this study was to evaluate infants, born to women with SARS-CoV-2 detected during pregnancy, for evidence of haematological abnormalities or hypercoagulability in umbilical cord blood. Study design: This was a prospective observational case-control study of infants born to women who had SARS-CoV-2 RNA detected by PCR at any time during their pregnancy (n = 15). The study was carried out in a Tertiary University Maternity Hospital (8,500 deliveries/year) in Ireland. This study was approved by the Hospital Research Ethics Committee and written consent was obtained. Umbilical cord blood samples were collected at delivery, full blood count and Calibrated Automated Thrombography were performed. Demographics and clinical outcomes were recorded. Healthy term infants, previously recruited as controls to a larger study prior to the outbreak of COVID-19, were the historical control population (n = 10). Results: Infants born to women with SARS-CoV-2 had similar growth parameters (birth weight 3600 g v 3680 g, p = 0.83) and clinical outcomes to healthy controls, such as need for resuscitation at birth (2 (13.3%) v 1 (10%), p = 1.0) and NICU admission (1 (6.7%) v 2 (20%), p = 0.54). Haematological parameters (Haemoglobin, platelet, white cell and lymphocyte counts) in the COVID-19 group were all within normal neonatal reference ranges. Calibrated Automated Thrombography revealed no differences in any thrombin generation parameters (lag time (p = 0.92), endogenous thrombin potential (p = 0.24), peak thrombin (p = 0.44), time to peak thrombin (p = 0.94)) between the two groups. Conclusion: In this prospective study including eligible cases in a very large population of approximately 1500 women, there was no evidence of derangement of the haematological parameters or hypercoagulability in umbilical cord blood due to COVID-19. Further research is required to investigate the pathological placental changes, particularly COVID-19 placentitis and the impact of different strains of SARS-CoV-2 (particularly the B.1.1.7 and the emerging Delta variant) and the severity and timing of infection on the developing fetus.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.urlhttps://www.ejog.org/article/S0301-2115(21)00471-1/fulltexten_US
dc.rightsCopyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.
dc.subjectCongenital infectionen_US
dc.subjectPlacentaen_US
dc.subjectPrematurityen_US
dc.subjectSARS-CoV-2en_US
dc.subjectTHROMBOSISen_US
dc.subject.otherAccess Awards 2021 Submissionen_US
dc.subject.otherCovid-19en_US
dc.subject.otherAcute Care and Hospitalsen_US
dc.titleHaematological parameters and coagulation in umbilical cord blood following COVID-19 infection in pregnancy.en_US
dc.typeArticleen_US
dc.typeOtheren_US
dc.identifier.eissn1872-7654
dc.contributor.departmentDepartment of Paediatrics, Royal College of Surgeons in Ireland, Dublin, Ireland; Department of Neonatology, Rotunda Hospital, Dublin, Ireland; Conway-SPHERE Research Group, Conway Institute, University College Dublin, Ireland. Electronic address: claireamurphy@rcsi.com. 2Department of Neonatology, Rotunda Hospital, Dublin, Ireland; Conway-SPHERE Research Group, Conway Institute, University College Dublin, Ireland. 3Conway-SPHERE Research Group, Conway Institute, University College Dublin, Ireland; School of Medicine, University College Dublin, Ireland. 4Conway-SPHERE Research Group, Conway Institute, University College Dublin, Ireland. 5Conway-SPHERE Research Group, Conway Institute, University College Dublin, Ireland; Department of Hematology, Mater Misericordiae University Hospital, Dublin, Ireland. 6Department of Paediatrics, Royal College of Surgeons in Ireland, Dublin, Ireland; Department of Neonatology, Rotunda Hospital, Dublin, Ireland. 7Department of Pathology, Rotunda Hospital, Dublin, Ireland. 8Department of Obstetrics and Gynaecology, Rotunda Hospital, Dublin, Ireland; Department of Obstetrics and Gynaecology, Royal College of Surgeons in Ireland, Dublin, Ireland. 9Department of Paediatrics, Royal College of Surgeons in Ireland, Dublin, Ireland; Department of Neonatology, Rotunda Hospital, Dublin, Ireland; Department of Paediatric Infectious Diseases, Children's Health Ireland at Temple Street, Dublin, Ireland. 10Irish Meningitis and Sepsis Reference Laboratory, Children's Health Ireland at Temple Street, Dublin, Ireland; Clinical Innovation Unit, Rotunda Hospital, Dublin, Ireland; Department of Microbiology, Royal College of Surgeons in Ireland, Dublin, Ireland. 11Department of Laboratory Medicine, Rotunda Hospital, Dublin, Ireland. 12Department of Neonatology, Liverpool Women's Hospital, Liverpool, United Kingdom; Department of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom. 13Conway-SPHERE Research Group, Conway Institute, University College Dublin, Ireland; School of Medicine, University College Dublin, Ireland; Department of Hematology, Mater Misericordiae University Hospital, Dublin, Ireland.en_US
dc.identifier.journalEuropean journal of obstetrics, gynecology, and reproductive biologyen_US
dc.description.peer-reviewpeer-reviewen_US
dc.source.journaltitleEuropean journal of obstetrics, gynecology, and reproductive biology
dc.source.volume266
dc.source.beginpage99
dc.source.endpage105
refterms.dateFOA2021-11-29T16:38:46Z
dc.source.countryIreland


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