Implicating androgen excess in propagating metabolic disease in polycystic ovary syndrome.
Issue Date
2020-06-24Keywords
C11-oxy C19 androgensPCOS
adipose tissue
androgens
DIABETES
metabolic disease
OBESITY
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Therapeutic advances in endocrinology and metabolismDOI
10.1177/2042018820934319PubMed ID
32637065Abstract
Polycystic ovary syndrome (PCOS) has been traditionally perceived as a reproductive disorder due to its most common presentation with menstrual dysfunction and infertility. However, it is now clear that women with PCOS are at increased risk of metabolic dysfunction, from impaired glucose tolerance and type 2 diabetes mellitus to nonalcoholic fatty liver disease and cardiovascular disease. PCOS is characterised by androgen excess, with cross-sectional data showing that hyperandrogenism is directly complicit in the development of metabolic complications. Recent studies have also shown that C11-oxy C19 androgens are emerging to be clinically and biochemically significant in PCOS, thus emphasising the importance of understanding the impact of both classic and C11-oxy C19 androgens on women's health. Here we discuss androgen metabolism in the context of PCOS, and dissect the role played by androgens in the development of metabolic disease through their effects on metabolic target tissues in women.Item Type
ArticleOther
Language
enISSN
2042-0188ae974a485f413a2113503eed53cd6c53
10.1177/2042018820934319
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