Developing a lung nodule management protocol specifically for cardiac CT: Methodology in the DISCHARGE trial.
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Issue Date
2020-06-25Keywords
ACR, American College of RadiologyADULT
Computed tomography angiography*
Incidental findings*
LDCT, low-dose computed tomography
Lung/diagnostic imaging
NLST, national lung cancer screening trial
eCRF, electronic clinical report form
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European journal of radiology openDOI
10.1016/j.ejro.2020.100235PubMed ID
32637465Abstract
Purpose: In this methodology paper we describe the development of a lung nodule management algorithm specifically for patients undergoing cardiac CT. Methods: We modified the Lung-RADS algorithm specifically to manage lung nodules incidentally detected on cardiac CT (Lung-RADS for cardiac CT). We will evaluate the modified algorithm as part of the DISCHARGE trial (www.dischargetrial.eu) in which patients with suspected coronary artery disease are randomly assigned to cardiac CT or invasive coronary angiography across Europe at 16 sites involving 3546 patients. Patients will be followed for up to four years. Results: The major adjustments to Lung-RADS specifically for cardiac CT relate to 1) incomplete coverage of the lungs by cardiac CT compared with chest CT, and when to order a completion chest CT versus a follow up chest CT, 2) cardiac CT findings will not trigger annual lung-cancer screening, and 3) a lower threshold of at least 10 mm for classifying new ground glass nodules as probably benign (category 3). Conclusions: The DISCHARGE trial will assess a lung nodule management algorithm designed specifically for cardiac CT in patients with stable chest pain across Europe.Item Type
ArticleLanguage
enISSN
2352-0477ae974a485f413a2113503eed53cd6c53
10.1016/j.ejro.2020.100235
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