Diagnostic Accuracy of Prion Disease Biomarkers in Iatrogenic Creutzfeldt-Jakob Disease.
Authors
Llorens, FrancVillar-Piqué, Anna
Hermann, Peter
Schmitz, Matthias
Calero, Olga
Stehmann, Christiane
Sarros, Shannon
Moda, Fabio
Ferrer, Isidre
Poleggi, Anna
Pocchiari, Maurizio
Catania, Marcella
Klotz, Sigrid
O'Regan, Carl
Brett, Francesca
Heffernan, Josephine
Ladogana, Anna
Collins, Steven J
Calero, Miguel
Kovacs, Gabor G
Zerr, Inga
Issue Date
2020-02-12Keywords
Iatrogenic Creutzfeldt-Jakob diseaseRT-QuIC
Biomarker
cerebrospinal fluid
corneal transplant
dura matter graft
electroencephalogram
growth hormone
magnetic resonance imaging
Metadata
Show full item recordJournal
BiomoleculesDOI
10.3390/biom10020290PubMed ID
32059611Abstract
Human prion diseases are classified into sporadic, genetic, and acquired forms. Within this last group, iatrogenic Creutzfeldt-Jakob disease (iCJD) is caused by human-to-human transmission through surgical and medical procedures. After reaching an incidence peak in the 1990s, it is believed that the iCJD historical period is probably coming to an end, thanks to lessons learnt from past infection sources that promoted new prion prevention and decontamination protocols. At this point, we sought to characterise the biomarker profile of iCJD and compare it to that of sporadic CJD (sCJD) for determining the value of available diagnostic tools in promptly recognising iCJD cases. To that end, we collected 23 iCJD samples from seven national CJD surveillance centres and analysed the electroencephalogram and neuroimaging data together with a panel of seven CSF biomarkers: 14-3-3, total tau, phosphorylated/total tau ratio, alpha-synuclein, neurofilament light, YKL-40, and real-time quaking induced conversion of prion protein. Using the cut-off values established for sCJD, we found the sensitivities of these biomarkers for iCJD to be similar to those described for sCJD. Given the limited relevant information on this issue to date, the present study validates the use of current sCJD biomarkers for the diagnosis of future iCJD cases.Item Type
ArticleOther
Language
enEISSN
2218-273Xae974a485f413a2113503eed53cd6c53
10.3390/biom10020290
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