Evaluation of wavelength ranges and tissue depth probed by diffuse reflectance spectroscopy for colorectal cancer detection.
Authors
Nogueira, Marcelo SaitoMaryam, Siddra
Amissah, Michael
Lu, Huihui
Lynch, Noel
Killeen, Shane
O'Riordain, Micheal
Andersson-Engels, Stefan
Affiliation
Mercy University Hospital, Grenville Place, Cork, IrelandIssue Date
2021-01-12Keywords
PHL Subject Categories::COLORECTAL CANCERLocal subject classification
diffuse reflectance spectroscopycolorectal cancer
neoplasms
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Nogueira, M.S., Maryam, S., Amissah, M. et al. Evaluation of wavelength ranges and tissue depth probed by diffuse reflectance spectroscopy for colorectal cancer detection. Sci Rep 11, 798 (2021). https://dx.doi.org/10.1038/s41598-020-79517-2Publisher
Nature ResearchJournal
Scientific reportsDOI
10.1038/s41598-020-79517-2PubMed ID
33436684Additional Links
https://www.nature.com/articles/s41598-020-79517-2Abstract
Colorectal cancer (CRC) is the third most common type of cancer worldwide and the second most deadly. Recent research efforts have focused on developing non-invasive techniques for CRC detection. In this study, we evaluated the diagnostic capabilities of diffuse reflectance spectroscopy (DRS) for CRC detection by building 6 classification models based on support vector machines (SVMs). Our dataset consists of 2889 diffuse reflectance spectra collected from freshly excised ex vivo tissues of 47 patients over wavelengths ranging from 350 and 1919 nm with source-detector distances of 630-µm and 2500-µm to probe different depths. Quadratic SVMs were used and performance was evaluated using twofold cross-validation on 10 iterations of randomized training and test sets. We achieved (93.5 ± 2.4)% sensitivity, (94.0 ± 1.7)% specificity AUC by probing the superficial colorectal tissue and (96.1 ± 1.8)% sensitivity, (95.7 ± 0.6)% specificity AUC by sampling deeper tissue layers. To the best of our knowledge, this is the first DRS study to investigate the potential of probing deeper tissue layers using larger SDD probes for CRC detection in the luminal wall. The data analysis showed that using a broader spectrum and longer near-infrared wavelengths can improve the diagnostic accuracy of CRC as well as probing deeper tissue layers. © 2021, The Author(s).Item Type
ArticleLanguage
enEISSN
2045-2322Sponsors
Science Foundation Ireland (Grant ID SFI/15/RP/2828)ae974a485f413a2113503eed53cd6c53
10.1038/s41598-020-79517-2
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- Creative Commons
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