Evaluation of wavelength ranges and tissue depth probed by diffuse reflectance spectroscopy for colorectal cancer detection.
AuthorsNogueira, Marcelo Saito
AffiliationMercy University Hospital, Grenville Place, Cork, Ireland
KeywordsPHL Subject Categories::COLORECTAL CANCER
Local subject classificationdiffuse reflectance spectroscopy
MetadataShow full item record
CitationNogueira, M.S., Maryam, S., Amissah, M. et al. Evaluation of wavelength ranges and tissue depth probed by diffuse reflectance spectroscopy for colorectal cancer detection. Sci Rep 11, 798 (2021). https://dx.doi.org/10.1038/s41598-020-79517-2
AbstractColorectal cancer (CRC) is the third most common type of cancer worldwide and the second most deadly. Recent research efforts have focused on developing non-invasive techniques for CRC detection. In this study, we evaluated the diagnostic capabilities of diffuse reflectance spectroscopy (DRS) for CRC detection by building 6 classification models based on support vector machines (SVMs). Our dataset consists of 2889 diffuse reflectance spectra collected from freshly excised ex vivo tissues of 47 patients over wavelengths ranging from 350 and 1919 nm with source-detector distances of 630-µm and 2500-µm to probe different depths. Quadratic SVMs were used and performance was evaluated using twofold cross-validation on 10 iterations of randomized training and test sets. We achieved (93.5 ± 2.4)% sensitivity, (94.0 ± 1.7)% specificity AUC by probing the superficial colorectal tissue and (96.1 ± 1.8)% sensitivity, (95.7 ± 0.6)% specificity AUC by sampling deeper tissue layers. To the best of our knowledge, this is the first DRS study to investigate the potential of probing deeper tissue layers using larger SDD probes for CRC detection in the luminal wall. The data analysis showed that using a broader spectrum and longer near-infrared wavelengths can improve the diagnostic accuracy of CRC as well as probing deeper tissue layers. © 2021, The Author(s).
SponsorsScience Foundation Ireland (Grant ID SFI/15/RP/2828)
The following license files are associated with this item:
- Creative Commons
- Toward complete oral cavity cancer resection using a handheld diffuse reflectance spectroscopy probe.
- Authors: Brouwer de Koning SG, Baltussen EJM, Karakullukcu MB, Dashtbozorg B, Smit LA, Dirven R, Hendriks BHW, Sterenborg HJCM, Ruers TJM
- Issue date: 2018 Oct
- Tissue diagnosis during colorectal cancer surgery using optical sensing: an in vivo study.
- Authors: Baltussen EJM, Brouwer de Koning SG, Sanders J, Aalbers AGJ, Kok NFM, Beets GL, Hendriks BHW, Sterenborg HJCM, Kuhlmann KFD, Ruers TJM
- Issue date: 2019 Oct 2
- Synergy of Fluorescence and Near-Infrared Spectroscopy in Detection of Colorectal Cancer.
- Authors: Ehlen L, Zabarylo UJ, Speichinger F, Bogomolov A, Belikova V, Bibikova O, Artyushenko V, Minet O, Beyer K, Kreis ME, Kamphues C
- Issue date: 2019 Oct
- Diffuse reflectance spectroscopy as a tool for real-time tissue assessment during colorectal cancer surgery.
- Authors: Baltussen EJM, Snaebjornsson P, de Koning SGB, Sterenborg HJCM, Aalbers AGJ, Kok N, Beets GL, Hendriks BHW, Kuhlmann KFD, Ruers TJM
- Issue date: 2017 Oct
- Diffuse reflectance spectroscopy to monitor murine colorectal tumor progression and therapeutic response.
- Authors: Mundo AI, Greening GJ, Fahr MJ, Hale LN, Bullard EA, Rajaram N, Muldoon TJ
- Issue date: 2020 Mar