• Association of ionizing radiation dose from common medical diagnostic procedures and lymphoma risk in the Epilymph case-control study.

      Pasqual, Elisa; Turner, Michelle C; Gracia-Lavedan, Esther; Casabonne, Delphine; Benavente, Yolanda; Chef, Isabelle Thierry; Maynadié, Marc; Cocco, Pierluigi; Staines, Anthony; Foretova, Lenka; et al. (2020-07-10)
    • Brain tumor segmentation based on deep learning and an attention mechanism using MRI multi-modalities brain images.

      Ranjbarzadeh, Ramin; Bagherian Kasgari, Abbas; Jafarzadeh Ghoushchi, Saeid; Anari, Shokofeh; Naseri, Maryam; Bendechache, Malika (2021-05-25)
    • Bringing Shame Out of the Shadows: Identifying Shame in Child Sexual Abuse Disclosure Processes and Implications for Psychotherapy.

      McElvaney, Rosaleen; Lateef, Rusan; Collin-Vézina, Delphine; Alaggia, Ramona; Simpson, Megan; Dublin City University, Dublin, Ireland. 2McGill University, Montreal, Canada. 3University of Toronto, Canada. 4Carlton University, Ottawa, Canada. (SAGE Journals, 2021-08-30)
    • The calcium binding protein S100β marks hedgehog-responsive resident vascular stem cells within vascular lesions.

      Di Luca, Mariana; Fitzpatrick, Emma; Burtenshaw, Denise; Liu, Weimin; Helt, Jay-Christian; Hakimjavadi, Roya; Corcoran, Eoin; Gusti, Yusof; Sheridan, Daniel; Harman, Susan; et al. (2021-03-01)
    • Clinical, laboratory and radiological characteristics and outcomes of novel coronavirus (SARS-CoV-2) infection in humans: A systematic review and series of meta-analyses.

      Borges do Nascimento, Israel Júnior; von Groote, Thilo Caspar; O'Mathúna, Dónal P; Abdulazeem, Hebatullah Mohamed; Henderson, Catherine; Jayarajah, Umesh; Weerasekara, Ishanka; Poklepovic Pericic, Tina; Klapproth, Henning Edgar Gerald; Puljak, Livia; et al. (2020-09-17)
    • DI-5-CUFFS: Venoconstrictive Thigh Cuffs Limit Body Fluid Changes but Not Orthostatic Intolerance Induced by a 5-Day Dry Immersion.

      Robin, Adrien; Auvinet, Aline; Degryse, Bernard; Murphy, Ronan; Bareille, Marie-Pierre; Beck, Arnaud; Gharib, Claude; Gauquelin-Koch, Guillemette; Daviet, Aude; Larcher, Françoise; et al. (2020-05-05)
    • Efficacy of Phytocannabinoids in Epilepsy Treatment: Novel Approaches and Recent Advances.

      Farrelly, Aaron M; Vlachou, Styliani; Grintzalis, Konstantinos (2021-04-10)
      Epilepsy is a neurological disorder mainly characterised by recurrent seizures that affect the entire population diagnosed with the condition. Currently, there is no cure for the disease and a significant proportion of patients have been deemed to have treatment-resistant epilepsy (TRE). A patient is deemed to have TRE if two or more antiepileptic drugs (AEDs) fail to bring about seizure remission. This inefficacy of traditional AEDs, coupled with their undesirable side effect profile, has led to researchers considering alternative forms of treatment. Phytocannabinoids have long served as therapeutics with delta-9-THC (Δ9-THC) receiving extensive focus to determine its therapeutic potential. This focus on Δ9-THC has been to the detriment of analysing the plethora of other phytocannabinoids found in the cannabis plant. The overall aim of this review is to explore other novel phytocannabinoids and their place in epilepsy treatment. The current review intends to achieve this aim via an exploration of the molecular targets underlying the anticonvulsant capabilities of cannabidiol (CBD), cannabidavarin (CBDV), delta-9-tetrahydrocannabivarin (Δ9-THCV) and cannabigerol (CBG). Further, this review will provide an exploration of current pre-clinical and clinical data as it relates to the aforementioned phytocannabinoids and the treatment of epilepsy symptoms. With specific reference to epilepsy in young adult and adolescent populations, the exploration of CBD, CBDV, Δ9-THCV and CBG in both preclinical and clinical environments can guide future research and aid in the further understanding of the role of phytocannabinoids in epilepsy treatment. Currently, much more research is warranted in this area to be conclusive.
    • Evaluation of the Use of Single- and Multi-Magnification Convolutional Neural Networks for the Determination and Quantitation of Lesions in Nonclinical Pathology Studies.

      Kuklyte, Jogile; Fitzgerald, Jenny; Nelissen, Sophie; Wei, Haolin; Whelan, Aoife; Power, Adam; Ahmad, Ajaz; Miarka, Martyna; Gregson, Mark; Maxwell, Michael; et al. (2021-02-23)
    • An Extended Approach to Predict Retinopathy in Diabetic Patients Using the Genetic Algorithm and Fuzzy C-Means.

      Ghoushchi, Saeid Jafarzadeh; Ranjbarzadeh, Ramin; Dadkhah, Amir Hussein; Pourasad, Yaghoub; Bendechache, Malika (2021-06-26)
    • Factors influencing physical activity in adults with cystic fibrosis.

      Hurley, Nicola; Moyna, Niall M; Kehoe, Bróna; McCaffrey, Noel; Redmond, Karen; Hardcastle, Sarah J (2021-04-02)
    • Formative Evaluation of a Home-Based Physical Activity Intervention for Adolescent Girls-The HERizon Project: A Randomised Controlled Trial.

      Cowley, Emma S; Watson, Paula M; Foweather, Lawrence; Belton, Sarahjane; Mansfield, Chiara; Whitcomb-Khan, Gabriella; Cacciatore, Isabella; Thompson, Andrew; Thijssen, Dick; Wagenmakers, Anton J M (2021-01-22)
      A total of 42 female participants, aged 13 to 16 years old (mean = 14.2, SD = 1.1), were randomly allocated to: (i) the HERizon group (n = 22) or (ii) the wait-list control group (n = 20). Participants in the six-week HERizon group were asked to complete three PA sessions each week and engage in weekly behaviour change support video calls. The primary outcome measure was self-reported habitual PA. Secondary outcomes measures included cardiorespiratory fitness (20 m shuttle run), muscular strength (standing long jump), muscular endurance (push up test), and psychosocial outcomes (Perceived Competence Scale, Body Appreciation Scale, Self-Esteem Questionnaire, Behavioural Regulation in Exercise Questionnaire). Quantitative and qualitative process evaluation data were also collected. Outcome measures were assessed at baseline and after the six-week intervention.
    • Genetically Determined Height and Risk of Non-hodgkin Lymphoma.

      Moore, Amy; Kane, Eleanor; Wang, Zhaoming; Panagiotou, Orestis A; Teras, Lauren R; Monnereau, Alain; Wong Doo, Nicole; Machiela, Mitchell J; Skibola, Christine F; Slager, Susan L; et al. (2020-01-28)
      Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00-1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01-1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.
    • "Girls Aren't Meant to Exercise": Perceived Influences on Physical Activity among Adolescent Girls-The HERizon Project.

      Cowley, Emma S; Watson, Paula M; Foweather, Lawrence; Belton, Sarahjane; Thompson, Andrew; Thijssen, Dick; Wagenmakers, Anton J M (2021-01-07)
      A total of 48 adolescent girls (13-18 years) from low socioeconomic areas of the United Kingdom and Ireland participated in focus groups (n = 8), to explore perspectives of physical activity and the influence of gender within this. Focus groups were thematically analyzed and interpreted within a socioecological framework.
    • Global genome diversity of the complex.

      Franssen, Susanne U; Durrant, Caroline; Stark, Olivia; Moser, Bettina; Downing, Tim; Imamura, Hideo; Dujardin, Jean-Claude; Sanders, Mandy J; Mauricio, Isabel; Miles, Michael A; et al. (2020-03-25)
      Protozoan parasites of the Leishmania donovani complex - L. donovani and L. infantum - cause the fatal disease visceral leishmaniasis. We present the first comprehensive genome-wide global study, with 151 cultured field isolates representing most of the geographical distribution. L. donovani isolates separated into five groups that largely coincide with geographical origin but vary greatly in diversity. In contrast, the majority of L. infantum samples fell into one globally-distributed group with little diversity. This picture is complicated by several hybrid lineages. Identified genetic groups vary in heterozygosity and levels of linkage, suggesting different recombination histories. We characterise chromosome-specific patterns of aneuploidy and identified extensive structural variation, including known and suspected drug resistance loci. This study reveals greater genetic diversity than suggested by geographically-focused studies, provides a resource of genomic variation for future work and sets the scene for a new understanding of the evolution and genetics of the Leishmania donovani complex.
    • Health Literacy in Schools? A Systematic Review of Health-Related Interventions Aimed at Disadvantaged Adolescents.

      Smith, Craig; Goss, Hannah; Issartel, Johann; Belton, Sarahjane (2021-02-25)
      Socioeconomically disadvantaged populations are at greater risk of adopting unhealthy behaviours and developing chronic diseases. Adolescence has been identified as a crucial life stage to develop lifelong healthy behaviours, with schools often suggested as the ideal environment to foster healthy habits. Health literacy (HL) provides a possible solution to promote such healthy behaviours. The aim of this study was to review school-based HL-related interventions targeting socioeconomically disadvantaged adolescents and to identify effective intervention strategies for this population. Searches were performed in six databases. Inclusion criteria included age: 12-16; the implementation of a school-based intervention related to HL aimed at socioeconomically disadvantaged populations; an intervention focused on: physical activity (PA), diet, mental health, substance abuse or sleep. Forty-one articles were included, with the majority focusing on PA and diet (n = 13), PA (n = 9) or mental health (n = 7). Few interventions focused solely on substance abuse (n = 2) or sleep (n = 1), and none targeted or assessed HL as an outcome measure. There was huge heterogeneity in study design, outcomes measures and effectiveness reported. Effective intervention strategies were identified that can be used to guide future interventions, including practical learning activities, peer support and approaches targeting the school environment, the parents or that link the intervention to the community.
    • How Are Consensual, Non-Consensual, and Pressured Sexting Linked to Depression and Self-Harm? The Moderating Effects of Demographic Variables.

      Wachs, Sebastian; Wright, Michelle F; Gámez-Guadix, Manuel; Döring, Nicola (2021-03-05)
      Sexting among adolescents has triggered controversial debates among scholars and the general public. However, questions regarding the associations between different types of sexting, namely consensual, non-consensual, and pressured sexting, depressive symptoms, and non-suicidal self-harm remain. In addition, little attention has been given to whether demographic variables (i.e., gender, ethnicity, disability, sexual minority) might influence these associations. To fill these gaps in the literature, the present study was conducted. Participants were 2506 adolescents (ages 13-16 years old; Mage = 15.17; SDage = 0.89) from eight high schools located in the suburbs of a large Midwestern city in the United States. Adolescents self-identified as female (50%), Caucasian (57%), approximately 15% reported that they had a disability they received school accommodation for, and 18% self-identified as a sexual minority. They completed self-report questionnaires on their sexting behaviors, depressive symptoms, and non-suicidal self-harm. Findings revealed that non-consensual and pressured sexting were positively related to depressive symptoms and non-suicidal self-harm, whereas consensual sexting was unrelated to these outcomes. Boys engaged in more non-consensual sexting compared with girls, girls were more pressured to send sexts compared with boys, and sexual minority adolescents reported greater consensual sexting compared with non-sexual minority adolescents. Moderating effects revealed that girls, non-minority adolescents, and non-sexual minority adolescents experienced greater depressive symptoms and non-suicidal self-harm when they experienced pressured sexting. These findings underscore the importance of considering various types of sexting and adolescents' demographic variables when examining the negative outcomes of sexting. Disentangling the relationships among different types of sexting, depressive symptoms, and self-harm aids in the development of evidence-based recommendations for sexting harm prevention and sexual education programs.
    • "How many times did I not want to live a life because of him": the complex connections between child sexual abuse, disclosure, and self-injurious thoughts and behaviors.

      Collin-Vézina, Delphine; De La Sablonnière-Griffin, Mireille; Sivagurunathan, Marudan; Lateef, Rusan; Alaggia, Ramona; McElvaney, Rosaleen; Simpson, Megan (2021-01-04)
    • How to promote exclusive breastfeeding in Ireland: a qualitative study on views of Chinese immigrant mothers.

      Chen, Haoyue; Li, Cheng; Zhou, Qianling; Cassidy, Tanya M; Younger, Katherine M; Shen, Siao; Kearney, John M (2021-01-15)