• Association of ionizing radiation dose from common medical diagnostic procedures and lymphoma risk in the Epilymph case-control study.

      Pasqual, Elisa; Turner, Michelle C; Gracia-Lavedan, Esther; Casabonne, Delphine; Benavente, Yolanda; Chef, Isabelle Thierry; Maynadié, Marc; Cocco, Pierluigi; Staines, Anthony; Foretova, Lenka; et al. (2020-07-10)
    • Clinical, laboratory and radiological characteristics and outcomes of novel coronavirus (SARS-CoV-2) infection in humans: A systematic review and series of meta-analyses.

      Borges do Nascimento, Israel Júnior; von Groote, Thilo Caspar; O'Mathúna, Dónal P; Abdulazeem, Hebatullah Mohamed; Henderson, Catherine; Jayarajah, Umesh; Weerasekara, Ishanka; Poklepovic Pericic, Tina; Klapproth, Henning Edgar Gerald; Puljak, Livia; et al. (2020-09-17)
    • DI-5-CUFFS: Venoconstrictive Thigh Cuffs Limit Body Fluid Changes but Not Orthostatic Intolerance Induced by a 5-Day Dry Immersion.

      Robin, Adrien; Auvinet, Aline; Degryse, Bernard; Murphy, Ronan; Bareille, Marie-Pierre; Beck, Arnaud; Gharib, Claude; Gauquelin-Koch, Guillemette; Daviet, Aude; Larcher, Françoise; et al. (2020-05-05)
    • Genetically Determined Height and Risk of Non-hodgkin Lymphoma.

      Moore, Amy; Kane, Eleanor; Wang, Zhaoming; Panagiotou, Orestis A; Teras, Lauren R; Monnereau, Alain; Wong Doo, Nicole; Machiela, Mitchell J; Skibola, Christine F; Slager, Susan L; et al. (2020-01-28)
      Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00-1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01-1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.
    • Global genome diversity of the complex.

      Franssen, Susanne U; Durrant, Caroline; Stark, Olivia; Moser, Bettina; Downing, Tim; Imamura, Hideo; Dujardin, Jean-Claude; Sanders, Mandy J; Mauricio, Isabel; Miles, Michael A; et al. (2020-03-25)
      Protozoan parasites of the Leishmania donovani complex - L. donovani and L. infantum - cause the fatal disease visceral leishmaniasis. We present the first comprehensive genome-wide global study, with 151 cultured field isolates representing most of the geographical distribution. L. donovani isolates separated into five groups that largely coincide with geographical origin but vary greatly in diversity. In contrast, the majority of L. infantum samples fell into one globally-distributed group with little diversity. This picture is complicated by several hybrid lineages. Identified genetic groups vary in heterozygosity and levels of linkage, suggesting different recombination histories. We characterise chromosome-specific patterns of aneuploidy and identified extensive structural variation, including known and suspected drug resistance loci. This study reveals greater genetic diversity than suggested by geographically-focused studies, provides a resource of genomic variation for future work and sets the scene for a new understanding of the evolution and genetics of the Leishmania donovani complex.
    • Medical-attention injuries in community cricket: a systematic review.

      McLeod, Geordie; O'Connor, Siobhán; Morgan, Damian; Kountouris, Alex; Finch, Caroline F; Fortington, Lauren V (2020-03-18)
    • Novel Coronavirus Infection (COVID-19) in Humans: A Scoping Review and Meta-Analysis.

      Borges do Nascimento, Israel Júnior; Cacic, Nensi; Abdulazeem, Hebatullah Mohamed; von Groote, Thilo Caspar; Jayarajah, Umesh; Weerasekara, Ishanka; Esfahani, Meisam Abdar; Civile, Vinicius Tassoni; Marusic, Ana; Jeroncic, Ana; et al. (2020-03-30)
      A growing body of literature on the 2019 novel coronavirus (SARS-CoV-2) is becoming available, but a synthesis of available data has not been conducted. We performed a scoping review of currently available clinical, epidemiological, laboratory, and chest imaging data related to the SARS-CoV-2 infection. We searched MEDLINE, Cochrane CENTRAL, EMBASE, Scopus and LILACS from 01 January 2019 to 24 February 2020. Study selection, data extraction and risk of bias assessment were performed by two independent reviewers. Qualitative synthesis and meta-analysis were conducted using the clinical and laboratory data, and random-effects models were applied to estimate pooled results. A total of 61 studies were included (59,254 patients). The most common disease-related symptoms were fever (82%, 95% confidence interval (CI) 56%-99%; n = 4410), cough (61%, 95% CI 39%-81%; n = 3985), muscle aches and/or fatigue (36%, 95% CI 18%-55%; n = 3778), dyspnea (26%, 95% CI 12%-41%; n = 3700), headache in 12% (95% CI 4%-23%, n = 3598 patients), sore throat in 10% (95% CI 5%-17%, n = 1387) and gastrointestinal symptoms in 9% (95% CI 3%-17%, n = 1744). Laboratory findings were described in a lower number of patients and revealed lymphopenia (0.93 × 109/L, 95% CI 0.83-1.03 × 109/L, n = 464) and abnormal C-reactive protein (33.72 mg/dL, 95% CI 21.54-45.91 mg/dL; n = 1637). Radiological findings varied, but mostly described ground-glass opacities and consolidation. Data on treatment options were limited. All-cause mortality was 0.3% (95% CI 0.0%-1.0%; n = 53,631). Epidemiological studies showed that mortality was higher in males and elderly patients. The majority of reported clinical symptoms and laboratory findings related to SARS-CoV-2 infection are non-specific. Clinical suspicion, accompanied by a relevant epidemiological history, should be followed by early imaging and virological assay.
    • Occupational exposure to ionizing radiation and risk of lymphoma subtypes: results of the Epilymph European case-control study.

      Satta, Giannina; Loi, Matteo; Becker, Nickolaus; Benavente, Yolanda; de Sanjose, Silvia; Foretova, Lenka; Staines, Anthony; Maynadie, Marc; Nieters, Alexandra; Meloni, Federico; et al. (2020-04-25)
    • #StayHome: Monitoring and benchmarking social isolation trends in Caruaru and the Região Metropolitana do Recife during the COVID-19 pandemic.

      Endo, Patricia Takako; Silva, Ivanovitch; Lima, Luciana; Bezerra, Leonardo; Gomes, Rafael; Ribeiro-Dantas, Marcel; Alves, Gisliany; Monteiro, Kayo Henrique de Carvalho; Lynn, Theo; Sampaio, Vanderson de Souza (2020-06-24)
    • Suggestions to Improve the Comprehensibility of Current Definitions of Scientific Authorship for International Authors.

      Hosseini, Mohammad; Consoli, Luca; Zwart, H A E; van den Hoven, Mariette A (2019-04-23)
    • Ten Years of 'Flying the Flag': An Overview and Retrospective Consideration of the Active School Flag Physical Activity Initiative for Children-Design, Development & Evaluation.

      Belton, Sarahjane; Britton, Úna; Murtagh, Elaine; Meegan, Sarah; Duff, Christina; McGann, Jamie; School of Health & Human Performance, Dublin City University, D09 V209 Dublin 9, Ireland. (2020-12-16)
      Whole-school physical activity (PA) promotion programmes are recommended to increase youth PA. Evaluation of programmes is essential to ensure practice is guided by evidence. This paper evaluates the Active School Flag (ASF), a whole-school PA promotion programme in Ireland, using the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework. ASF was evaluated across three levels-(1) administration, (2) application, (3) outcomes-using a mi✗ed-methods case study design. E✗isting data sources were reviewed, the programme coordinator was interviewed, and a pilot study was conducted to investigate impact on 3rd and 5th class students (3 schools, n = 126 students, age range 8-12 years). In-school Moderate to Vigorous Physical Activity (MVPA; by accelerometery), motivation for PA (BREQ), PA self-efficacy (PASES), school affect and peer social support (Kidscreen27) were measured pre-programme (0 months), post-programme (8 months), and at retention (12 months). Teacher perceptions of classroom behaviour (CBAST) were also measured pre- and post-programme. ASF has been successful in engaging 46% of primary schools nationally. Students' in-school moderate-vigorous PA increased in all pilot-study schools from pre-programme to retention (η2 = 0.68-0.84). ASF programme design facilitates implementation fidelity, adoption and maintenance through buy in from schools and government stakeholders. ASF presents as an effective PA promotion programme in the short-to-medium term for primary schools. This RE-AIM evaluation provides evidence of ASF effectiveness, alongside valuable findings that could support programme improvement, and inform future similar programmes.
    • A validation study of the ICECAP-O in informal carers of people with dementia from eight European Countries.

      Perry-Duxbury, Meg; van Exel, Job; Brouwer, Werner; Sköldunger, Anders; Gonçalves-Pereira, Manuel; Irving, Kate; Meyer, Gabriele; Selbæk, Geir; Woods, Bob; Zanetti, Orazio; et al. (2019-10-08)
    • Ways Ahead: developing a supported self-management programme for people living with low- and intermediate-grade gliomas - a protocol for a multi-method study.

      Rimmer, Ben; Dutton, Lizzie; Lewis, Joanne; Burns, Richéal; Gallagher, Pamela; Williams, Sophie; Araujo-Soares, Vera; Finch, Tracy; Sharp, Linda (2020-07-29)
    • What Keeps Them Physically Active? Predicting Physical Activity, Motor Competence, Health-Related Fitness, and Perceived Competence in Irish Adolescents after the Transition from Primary to Second-Level School.

      Britton, Una; Issartel, Johann; Symonds, Jennifer; Belton, Sarahjane (2020-04-21)
      Physical activity (PA) decreases with age. The school transition is noted for significant changes in PA behaviour. Motor competence (MC), health-related fitness (HRF), and perceived competence (PC) are generally positively associated with PA. The aim of this study was to examine longitudinal cross-lagged relationships between PA, MC, HRF, and PC across the school transition from final year of primary school to first year of second-level school in Irish youth. PA (accelerometery), object-control and locomotor MC (TGMD-III), PC (perceived athletic competence subscale of the Self-Perception Profile for Adolescents), and HRF (20 m shuttle run, horizontal jump, vertical jump, push-ups, curl-ups) were measured in final year of primary school (6th class) and first year of second-level school (1st year). In the sixth class, 261 participants (53% female; mean age 12.22 ± 0.48 years) were tested. In first year, 291 participants (48% female; mean age: 13.20 ± 0.39 years) were tested. In total, 220 participants were involved in the study at both timepoints. Cross-lagged regression in AMOS23, using full information maximum likelihood estimation, was conducted to test reciprocal and predictive pathways between variables. The full cross-lagged model showed acceptable fit (χ2 = 69.12, df = 8, p < 0.01, NFI = 0.93, CFI = 0.94). HRF was the strongest predictor of future PA (β = 0.353), and also predicted PC (β = 0.336) and MC (β = 0.163). Object-control MC predicted future PA (β = 0.192). Reciprocal relationships existed between object-control MC and PA, and between object-control MC and PC. HRF was the strongest predictor of PA. Object-control MC also predicted PA. PA promotion strategies should target the development of HRF and object-control MC in primary school to reduce the decline in PA frequently observed after the school transition.