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    Sepsis Associated Delirium.

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    Authors
    Atterton, Ben
    Paulino, Maria Carolina
    Povoa, Pedro
    Martin-Loeches, Ignacio
    Issue Date
    2020-05-18
    Keywords
    ICU
    delirium
    dexmedetomidine
    Sepsis
    
    Metadata
    Show full item record
    Journal
    Medicina (Kaunas, Lithuania)
    URI
    http://hdl.handle.net/10147/628125
    DOI
    10.3390/medicina56050240
    PubMed ID
    32443606
    Abstract
    Sepsis is a potentially life-threatening condition caused by a systemic dysregulated host response to infection. The brain is particularly susceptible to the effects of sepsis with clinical manifestations ranging from mild confusion to a deep comatose state. Sepsis-associated delirium(SAD) is a cerebral manifestation commonly occurring in patients with sepsis and is thought to occur due to a combination of neuroinflammation and disturbances in cerebral perfusion, the blood brain barrier (BBB) and neurotransmission. The neurological impairment associated with SAD can persist for months or even longer, after the initial septic episode has subsided which may impair the rehabilitation potential of sepsis survivors. Early identification and treatment of the underlying sepsis is key in the management of SAD as once present it can be difficult to control. Through the regular use of validated screening tools for delirium, cases of SAD can be identified early; this allows potentially aggravating factors to be addressed promptly. The usefulness of biomarkers, neuroimaging and electroencephalopathy (EEG) in the diagnosis of SAD remains controversial. The Society of Critical Care Medicine (SCCM) guidelines advise against the use of medications to treat delirium unless distressing symptoms are present or it is hindering the patient’s ability to wean from organ support.
    Item Type
    Article
    Other
    Language
    en
    EISSN
    1648-9144
    ae974a485f413a2113503eed53cd6c53
    10.3390/medicina56050240
    Scopus Count
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    St. James's Hospital

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