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    Emerging treatments for inflammatory bowel disease.

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    Authors
    Hazel, Karl
    O'connor, Anthony
    Issue Date
    2020-02-05
    Keywords
    Crohn’s disease
    INFLAMMATORY BOWEL DISEASE
    ulcerative colitis
    
    Metadata
    Show full item record
    Journal
    Therapeutic advances in chronic disease
    URI
    http://hdl.handle.net/10147/628123
    DOI
    10.1177/2040622319899297
    PubMed ID
    32076497
    Additional Links
    https://journals.sagepub.com/doi/10.1177/2040622319899297?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200www.ncbi.nlm.nih.gov
    Abstract
    Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation, a relapsing and remitting clinical course, requirement for lifelong medication and often, significant morbidity. While multiple effective therapeutic options exist for the treatment of IBD, a proportion of patients will either fail to respond or lose response to therapy. Advances in therapeutics, such as the gut-specific anti-integrins, now offer patients an alternative option to systemic immunosuppression. Anti-interleukin 12 (anti-IL-12)/IL-23 agents offer new and effective treatment options for CD, while the oral small molecules now offer an oral alternative for the treatment of moderate-to-severe disease, previously requiring subcutaneous injection or intravenous infusion. Alternatives to pharmacological treatment such as stem-cell transplant and faecal microbiota transplant are also showing some promise in the treatment of both CD and UC.
    Item Type
    Article
    Other
    Language
    en
    ISSN
    2040-6223
    ae974a485f413a2113503eed53cd6c53
    10.1177/2040622319899297
    Scopus Count
    Collections
    Tallaght University Hospital

    entitlement

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