Rapid Evidence Review: Clinical evidence on the use of pharmacological prophylactic therapy in healthcare workers or contacts of cases of COVID-19 [v6.0]
dc.contributor.author | National Centre for Pharmacoeconomics | |
dc.contributor.author | COVID-19 Evidence Review Group for Medicines | |
dc.date.accessioned | 2020-07-31T09:52:40Z | |
dc.date.available | 2020-07-31T09:52:40Z | |
dc.date.issued | 2020-06-29 | |
dc.identifier.uri | http://hdl.handle.net/10147/627950 | |
dc.description | Infection among healthcare workers (HCWs) places an extra burden on healthcare environments at a crucial time due to staff absence and spread to family members. Healthcare workers who are front facing/ have regular patient contact, have been identified as a priority case for testing in Ireland and the infection rate among HCWs is approximately 32.2% of all cases confirmed to date. There is currently no robust evidence to support the use of prophylactic therapy in healthcare workers or those in contact with cases of COVID-19. A number of trials are ongoing examining the use of the following compounds, as prophylactic therapies in COVID-19 (hydroxychloroquine, chloroquine, lopinavir/ritonavir, inhaled nitric oxide gas, BCG vaccination, emtricitabine/tenofovir, vitamins in combination with hydroxychloroquine, lactobacillus coryniformis, levamisole and isoprinosine, nitazoxanide, measles vaccine, melatonin, recombinant human interferon alpha 1b spray, Peginterferon Lambda-1a, mefloquine, vitamin D, MMR vaccine, VPM1002 and a dendritic cell vaccine, emtricitabine/tenofovir alafenamide, GLS-1200, bromhexine, dietary supplementation in an oropharygeal spray), quercetin, lactoferrin, ivermectin. The completion of trials may better inform whether this strategy is beneficial as a means of transmission risk reduction in this high-risk group. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Health Information and Quality Authority (HIQA) | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | CORONAVIRUS | en_US |
dc.subject | INFECTION PREVENTION AND CONTROL | en_US |
dc.subject | HEALTHCARE WORKERS | en_US |
dc.subject | MEDICINES | en_US |
dc.title | Rapid Evidence Review: Clinical evidence on the use of pharmacological prophylactic therapy in healthcare workers or contacts of cases of COVID-19 [v6.0] | en_US |
dc.type | Other | en_US |
dc.language.rfc3066 | English | |
refterms.dateFOA | 2020-07-31T09:52:41Z |