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dc.contributor.authorNational Centre for Pharmacoeconomics
dc.contributor.authorCOVID-19 Evidence Review Group for Medicines
dc.date.accessioned2020-07-31T09:52:40Z
dc.date.available2020-07-31T09:52:40Z
dc.date.issued2020-06-29
dc.identifier.urihttp://hdl.handle.net/10147/627950
dc.descriptionInfection among healthcare workers (HCWs) places an extra burden on healthcare environments at a crucial time due to staff absence and spread to family members. Healthcare workers who are front facing/ have regular patient contact, have been identified as a priority case for testing in Ireland and the infection rate among HCWs is approximately 32.2% of all cases confirmed to date. There is currently no robust evidence to support the use of prophylactic therapy in healthcare workers or those in contact with cases of COVID-19. A number of trials are ongoing examining the use of the following compounds, as prophylactic therapies in COVID-19 (hydroxychloroquine, chloroquine, lopinavir/ritonavir, inhaled nitric oxide gas, BCG vaccination, emtricitabine/tenofovir, vitamins in combination with hydroxychloroquine, lactobacillus coryniformis, levamisole and isoprinosine, nitazoxanide, measles vaccine, melatonin, recombinant human interferon alpha 1b spray, Peginterferon Lambda-1a, mefloquine, vitamin D, MMR vaccine, VPM1002 and a dendritic cell vaccine, emtricitabine/tenofovir alafenamide, GLS-1200, bromhexine, dietary supplementation in an oropharygeal spray), quercetin, lactoferrin, ivermectin. The completion of trials may better inform whether this strategy is beneficial as a means of transmission risk reduction in this high-risk group.en_US
dc.language.isoenen_US
dc.publisherHealth Information and Quality Authority (HIQA)en_US
dc.subjectCOVID-19en_US
dc.subjectCORONAVIRUSen_US
dc.subjectINFECTION PREVENTION AND CONTROLen_US
dc.subjectHEALTHCARE WORKERSen_US
dc.subjectMEDICINESen_US
dc.titleRapid Evidence Review: Clinical evidence on the use of pharmacological prophylactic therapy in healthcare workers or contacts of cases of COVID-19 [v6.0]en_US
dc.typeOtheren_US
dc.language.rfc3066English
refterms.dateFOA2020-07-31T09:52:41Z


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