Association of synovial tissue polyfunctional T-cells with DAPSA in psoriatic arthritis.
dc.contributor.author | Wade, Sarah M | |
dc.contributor.author | Canavan, Mary | |
dc.contributor.author | McGarry, Trudy | |
dc.contributor.author | Low, Candice | |
dc.contributor.author | Wade, Siobhan C | |
dc.contributor.author | Mullan, Ronan H | |
dc.contributor.author | Veale, Douglas J | |
dc.contributor.author | Fearon, Ursula | |
dc.date.accessioned | 2020-02-24T14:52:40Z | |
dc.date.available | 2020-02-24T14:52:40Z | |
dc.date.issued | 2019-01-09 | |
dc.identifier.pmid | 30626658 | |
dc.identifier.doi | 10.1136/annrheumdis-2018-214138 | |
dc.identifier.uri | http://hdl.handle.net/10147/627220 | |
dc.description.abstract | PsA synovial tissue infiltrating CD4+ T-cells expressed higher levels of interleukin (IL)-17A, interferon gamma (IFN-γ), GM-CSF and CD161, with parallel enrichment of Th1, Th17 and exTh17 T-helper subsets (all p<0.05). Interestingly, a significant proportion of synovial T-cell subsets were triple-positive for GM-CSF, tumour necrosis factor (-TNF), -IL-17 or IFN-γ compared with matched blood (all p<0.05). Importantly, frequencies of polyfunctional T-cells correlated with DAPSA: Th1-GM-CSF+/TNF+/IFN-γ+ (r=0.7, p<0.01), Th17-GM-CSF+/TNF+/IL-17+ (r=0.6, p<0.057) and exTh17-GM-CSF+/TNF+/IFN-γ+ (r=0.7, p=0.0096), with no associations observed for single cytokine-producing T-cells. Following ex vivo culture of PsA synovial tissue cell suspensions, polyfunctional GM-CSF+TNFα+IL-17A+ or/IFN-γ+-producing T-cells (p<0.05), but not single cytokine-producing T-cells, were inhibited with a PDE4 inhibitor. Conclusion: These data demonstrate enrichment of polyfunctional T-cells in PsA synovial tissue which were strongly associated with DAPSA and ex vivo therapeutic response. | en_US |
dc.language.iso | en | en_US |
dc.rights | © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. | |
dc.subject | polyfunctional t-cells | en_US |
dc.subject | psoriatic arthritis | en_US |
dc.subject | synovial tissue | en_US |
dc.subject | CELL BIOLOGY | en_US |
dc.title | Association of synovial tissue polyfunctional T-cells with DAPSA in psoriatic arthritis. | en_US |
dc.type | Article | en_US |
dc.type | Other | en_US |
dc.identifier.eissn | 1468-2060 | |
dc.identifier.journal | Annals of the rheumatic diseases | en_US |
dc.description.peer-review | peer-review | en_US |
dc.source.journaltitle | Annals of the rheumatic diseases | |
dc.source.volume | 78 | |
dc.source.issue | 3 | |
dc.source.beginpage | 350 | |
dc.source.endpage | 354 | |
refterms.dateFOA | 2020-02-24T14:52:41Z | |
dc.source.country | England |