• Login
    View Item 
    •   Home
    • Hospital Research
    • Leinster
    • St. Vincent's University Hospital
    • View Item
    •   Home
    • Hospital Research
    • Leinster
    • St. Vincent's University Hospital
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    4715
    UlsterS
    4715
    Connacht
    1603
    Munster
    48
    Leinster
    426

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideNational Health Library & Knowledge ServiceGuide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementRIAN Pathways to Irish ResearchHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Display statistics

    Association of synovial tissue polyfunctional T-cells with DAPSA in psoriatic arthritis.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    350.full.pdf
    Size:
    1.627Mb
    Format:
    PDF
    Download
    Authors
    Wade, Sarah M
    Canavan, Mary
    McGarry, Trudy
    Low, Candice
    Wade, Siobhan C
    Mullan, Ronan H
    Veale, Douglas J
    Fearon, Ursula
    Issue Date
    2019-01-09
    Keywords
    polyfunctional t-cells
    psoriatic arthritis
    synovial tissue
    CELL BIOLOGY
    
    Metadata
    Show full item record
    Journal
    Annals of the rheumatic diseases
    URI
    http://hdl.handle.net/10147/627220
    DOI
    10.1136/annrheumdis-2018-214138
    PubMed ID
    30626658
    Abstract
    PsA synovial tissue infiltrating CD4+ T-cells expressed higher levels of interleukin (IL)-17A, interferon gamma (IFN-γ), GM-CSF and CD161, with parallel enrichment of Th1, Th17 and exTh17 T-helper subsets (all p<0.05). Interestingly, a significant proportion of synovial T-cell subsets were triple-positive for GM-CSF, tumour necrosis factor (-TNF), -IL-17 or IFN-γ compared with matched blood (all p<0.05). Importantly, frequencies of polyfunctional T-cells correlated with DAPSA: Th1-GM-CSF+/TNF+/IFN-γ+ (r=0.7, p<0.01), Th17-GM-CSF+/TNF+/IL-17+ (r=0.6, p<0.057) and exTh17-GM-CSF+/TNF+/IFN-γ+ (r=0.7, p=0.0096), with no associations observed for single cytokine-producing T-cells. Following ex vivo culture of PsA synovial tissue cell suspensions, polyfunctional GM-CSF+TNFα+IL-17A+ or/IFN-γ+-producing T-cells (p<0.05), but not single cytokine-producing T-cells, were inhibited with a PDE4 inhibitor. Conclusion: These data demonstrate enrichment of polyfunctional T-cells in PsA synovial tissue which were strongly associated with DAPSA and ex vivo therapeutic response.
    Item Type
    Article
    Other
    Language
    en
    EISSN
    1468-2060
    ae974a485f413a2113503eed53cd6c53
    10.1136/annrheumdis-2018-214138
    Scopus Count
    Collections
    St. Vincent's University Hospital

    entitlement

    Related articles

    • Interleukin-17A Is Produced by CD4+ but Not CD8+ T Cells in Synovial Fluid Following T Cell Receptor Activation and Regulates Different Inflammatory Mediators Compared to Tumor Necrosis Factor in a Model of Psoriatic Arthritis Synovitis.
    • Authors: Xu X, Davelaar N, Mus AM, Asmawidjaja PS, Hazes JMW, Baeten DLP, Vis M, Bisoendial RJ, Prens EP, Lubberts E
    • Issue date: 2020 Aug
    • Polyfunctional, Proinflammatory, Tissue-Resident Memory Phenotype and Function of Synovial Interleukin-17A+CD8+ T Cells in Psoriatic Arthritis.
    • Authors: Steel KJA, Srenathan U, Ridley M, Durham LE, Wu SY, Ryan SE, Hughes CD, Chan E, Kirkham BW, Taams LS
    • Issue date: 2020 Mar
    • Relationship of CD146 expression to secretion of interleukin (IL)-17, IL-22 and interferon-γ by CD4(+) T cells in patients with inflammatory arthritis.
    • Authors: Wu C, Goodall JC, Busch R, Gaston JS
    • Issue date: 2015 Mar
    • Th17 and Th22 cells in psoriatic arthritis and psoriasis.
    • Authors: Benham H, Norris P, Goodall J, Wechalekar MD, FitzGerald O, Szentpetery A, Smith M, Thomas R, Gaston H
    • Issue date: 2013 Sep 26
    • The roles of IFN-γ versus IL-17 in pathogenic effects of human Th17 cells on synovial fibroblasts.
    • Authors: Kato H, Endres J, Fox DA
    • Issue date: 2013 Nov
    National Health Library & Knowledge Service | Health Service Executive | Dr Steevens' Hospital | Dublin 8 | Ireland
    lenus@hse.ie | Tel +353 (1) 6352558
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.