Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent infection.
AuthorsMullish, Benjamin H
McDonald, Julie A K
Allegretti, Jessica R
Barker, Grace F
Petrof, Elaine O
Joyce, Susan A
Gahan, Cormac G M
Williams, Horace R T
Clarke, Thomas B
Thursz, Mark R
Marchesi, Julian R
bile salt hydrolase
FAECAL MACROBIOTA TRANSPLANTATION
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AbstractFaecal microbiota transplant (FMT) effectively treats recurrent Clostridioides difficile infection (rCDI), but its mechanisms of action remain poorly defined. Certain bile acids affect C. difficile germination or vegetative growth. We hypothesised that loss of gut microbiota-derived bile salt hydrolases (BSHs) predisposes to CDI by perturbing gut bile metabolism, and that BSH restitution is a key mediator of FMT's efficacy in treating the condition.
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- Issue date: 2018 Nov
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