Recent Submissions

  • Population Health Management: A Position Paper

    Hayes, Catherine; Trinity College Dublin (Health Service Executive, 2022-11-21)
  • Use of cancer registry data to aid resource allocation for service planning [draft]

    Hayes, Catherine; Trinity College Dublin (Health Service Executive, 2019-07-01)
  • SARM1 Promotes Photoreceptor Degeneration in an Oxidative Stress Model of Retinal Degeneration.

    Gibbons, Luke; Ozaki, Ema; Greene, Chris; Trappe, Anne; Carty, Michael; Coppinger, Judith A; Bowie, Andrew G; Campbell, Matthew; Doyle, Sarah L (2022-04-01)
    SARM1 (sterile alpha and armadillo motif-containing protein) is a highly conserved Toll/IL-1 Receptor (TIR) adaptor with important roles in mediating immune responses. Studies in the brain have shown that SARM1 plays a role in induction of neuronal axon degeneration in response to a variety of injuries. We recently demonstrated that SARM1 is pro-degenerative in a genetic model of inherited retinopathy. This current study aimed to characterise the effect of SARM1 deletion in an alternative model of retinal degeneration (RD) in which the retinal pigment epithelium (RPE) fragments following administration of oxidising agent, sodium iodate (NaIO3), leading to subsequent photoreceptor cell death. Following administration of NaIO3, we observed no apparent difference in rate of loss of RPE integrity in SARM1 deficient mice compared to WT counterparts. However, despite no differences in RPE degeneration, photoreceptor cell number and retinal thickness were increased in Sarm1-/- mice compared to WT counterparts. This apparent protection of the photoreceptors in SARM1 deficient mice is supported by an observed decrease in pro-apoptotic caspase-3 in the photoreceptor layer of Sarm1-/- mice compared to WT. Together these data indicate a pro-degenerative role for SARM1 in the photoreceptors, but not in the RPE, in an oxidative stress induced model of retinal degeneration consistent with its known degenerative role in neurons in a range of neurodegenerative settings.
  • Population genomics confirms acquisition of drug-resistant Aspergillus fumigatus infection by humans from the environment.

    Rhodes, Johanna; Abdolrasouli, Alireza; Dunne, Katie; Sewell, Thomas R; Zhang, Yuyi; Ballard, Eloise; Brackin, Amelie P; van Rhijn, Norman; Chown, Harry; Tsitsopoulou, Alexandra; et al. (2022-04-25)
  • Dysphagia screening in residential care settings: A scoping review.

    Estupiñán-Artiles, Constantino; Regan, Julie; Donnellan, Claire (2020-10-28)
  • Embedding Physical Activity Within Community Home Support Services for Older Adults in Ireland - A Qualitative Study of Barriers and Enablers.

    Swan, Lauren; Horgan, N Frances; Cummins, Vanda; Burton, Elissa; Galvin, Rose; Skelton, Dawn A; Townley, Bex; Doyle, Frank; Jabakhanji, Samira B; Sorensen, Jan; et al. (2022-03-07)
  • Clinical diagnosis in paediatric patients at urban primary health care facilities in southern Malawi: a longitudinal observational study.

    Gondwe, Mtisunge Joshua; Henrion, Marc Y R; O'Byrne, Thomasena; Masesa, Clemens; Lufesi, Norman; Dube, Queen; Majamanda, Maureen D; Makwero, Martha; Lalloo, David G; Desmond, Nicola (2021-02-15)
  • Integrating machining learning and multimodal neuroimaging to detect schizophrenia at the level of the individual.

    Lei, Du; Pinaya, Walter H L; Young, Jonathan; van Amelsvoort, Therese; Marcelis, Machteld; Donohoe, Gary; Mothersill, David O; Corvin, Aiden; Vieira, Sandra; Huang, Xiaoqi; et al. (2019-11-18)
  • Pharmacological Evaluation of Crude CO Subcritical Extract after the Removal of Santonin by Means of High Speed Countercurrent Chromatography.

    Sakipova, Zuriyadda; Giorno, Thais Biondino Sardella; Bekezhanova, Tolkyn; Siu Hai Wong, Nikki; Shukirbekova, Alma; Fernandes, Patricia Dias; Boylan, Fabio (2020-06-12)
    Artemisia species are highly important due to their economic significance as medicines, fodder and food. Artemisia cina is an endemic species to Kazakhstan. In folk medicine, water extract of A. cina was used in the treatment of bronchial asthma while the alcohol extract has larvicidal and antituberculosis activity. The most common and most extensively studied compound from this species is the terpenoid santonin. The toxicity of this compound occurs at the doses of 60 mg for children and 200 mg for adults causing among other issues xanthopsia, leading to blindness. Having this in mind, the main idea of this work was to remove santonin from the crude extract and to check if the santonin-free extract would still be of any pharmacological importance. A CO2 subcritical extract was chromatographed using high-speed countercurrent chromatography (HSCCC) for the removal of santonin. The santonin-free CO2 subcritical extract (SFCO2E) as well as the isolated compound pectolinarigenin, a flavonoid, were assessed for their pharmacological actions. From the results obtained we can safely suggest that HSCCC is an efficient methodology to completely remove santonin from the CO2 subcritical extract. It was also possible to observe promising antinociceptive and anti-inflammatory activities for both SFCO2E and pectolinarigenin at concentrations that can justify the production of a phytomedicine with this endemic plant from Kazakhstan.
  • Does potentially inappropriate prescribing predict an increased risk of admission to hospital and mortality? A longitudinal study of the 'oldest old'.

    Cardwell, Karen; Kerse, Ngaire; Hughes, Carmel M; Teh, Ruth; Moyes, Simon A; Menzies, Oliver; Rolleston, Anna; Broad, Joanna B; Ryan, Cristín (2020-01-28)
  • Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation.

    Jones, Nicholas; Blagih, Julianna; Zani, Fabio; Rees, April; Hill, David G; Jenkins, Benjamin J; Bull, Caroline J; Moreira, Diana; Bantan, Azari I M; Cronin, James G; et al. (2021-02-22)
  • Impaired orthostatic heart rate recovery is associated with smaller thalamic volume: Results from The Irish Longitudinal Study on Aging (TILDA).

    De Looze, Céline; Williamson, Wilby; Hirst, Rebecca; O'Connor, John; Knight, Silvin; McCrory, Cathal; Carey, Daniel; Kenny, Rose-Anne (2020-04-30)
    The thalamus is a central hub of the autonomic network and thalamic volume has been associated with high-risk phenotypes for sudden cardiac death. Heart rate response to physiological stressors (e.g., standing) and the associated recovery patterns provide reliable indicators of both autonomic function and cardiovascular risk. Here we examine if thalamic volume may be a risk marker for impaired heart rate recovery in response to orthostatic challenge. The Irish Longitudinal Study on Aging involves a nationally representative sample of older individuals aged ≥50 years. Multimodal brain magnetic resonance imaging and orthostatic heart rate recovery were available for a cross-sectional sample of 430 participants. Multivariable regression and linear mixed-effects models were adjusted for head size, age, sex, education, body mass index, blood pressure, history of cardiovascular diseases and events, cardiovascular medication, diabetes mellitus, smoking, alcohol intake, timed up-and-go (a measure of physical frailty), physical exercise and depression. Smaller thalamic volume was associated with slower heart rate recovery (-1.4 bpm per 1 cm3 thalamic volume, 95% CI -2.01 to -0.82; p < .001). In multivariable analysis, participants with smaller thalamic volumes had a mean heart rate recovery -2.7 bpm slower than participants with larger thalamic volumes (95% CI -3.89 to -1.61; p < .001). Covariates associated with smaller thalamic volume included age, history of diabetes, and heavy alcohol consumption. Thalamic volume may be an indicator of the structural integrity of the central autonomic network. It may be a clinical biomarker for stratification of individuals at risk of autonomic dysfunction, cardiovascular events, and sudden cardiac death.
  • A systematic concept analysis of 'technology dependent': challenging the terminology.

    Brenner, Maria; Alexander, Denise; Quirke, Mary Brigid; Eustace-Cook, Jessica; Leroy, Piet; Berry, Jay; Healy, Martina; Doyle, Carmel; Masterson, Kate (2020-07-24)
  • A core outcome set for research and clinical practice in women with pelvic girdle pain: PGP-COS.

    Remus, Alexandria; Smith, Valerie; Gutke, Annelie; Mena, Juan Jose Saldaña; Mørkved, Siv; Wikmar, Lena Nilsson; Öberg, Birgitta; Olsson, Christina; Robinson, Hilde Stendal; Stuge, Britt; et al. (2021-02-25)
  • Delivering Behaviour Change Interventions: Development of a Mode of Delivery Ontology.

    Marques, Marta M; Carey, Rachel N; Norris, Emma; Evans, Fiona; Finnerty, Ailbhe N; Hastings, Janna; Jenkins, Ella; Johnston, Marie; West, Robert; Michie, Susan (2021-02-26)
    Background: Investigating and improving the effects of behaviour change interventions requires detailed and consistent specification of all aspects of interventions. An important feature of interventions is the way in which these are delivered, i.e. their mode of delivery. This paper describes an ontology for specifying the mode of delivery of interventions, which forms part of the Behaviour Change Intervention Ontology, currently being developed in the Wellcome Trust funded Human Behaviour-Change Project. Methods: The Mode of Delivery Ontology was developed in an iterative process of annotating behaviour change interventions evaluation reports, and consulting with expert stakeholders. It consisted of seven steps: 1) annotation of 110 intervention reports to develop a preliminary classification of modes of delivery; 2) open review from international experts (n=25); 3) second round of annotations with 55 reports to test inter-rater reliability and identify limitations; 4) second round of expert review feedback (n=16); 5) final round of testing of the refined ontology by two annotators familiar and two annotators unfamiliar with the ontology; 6) specification of ontological relationships between entities; and 7) transformation into a machine-readable format using the Web Ontology Language (OWL) and publishing online. Results: The resulting ontology is a four-level hierarchical structure comprising 65 unique modes of delivery, organised by 15 upper-level classes: Informational , Environmental change, Somatic, Somatic alteration, Individual-based/ Pair-based /Group-based, Uni-directional/Interactional, Synchronous/ Asynchronous, Push/ Pull, Gamification, Arts feature. Relationships between entities consist of is_a. Inter-rater reliability of the Mode of Delivery Ontology for annotating intervention evaluation reports was a=0.80 (very good) for those familiar with the ontology and a= 0.58 (acceptable) for those unfamiliar with it. Conclusion: The ontology can be used for both annotating and writing behaviour change intervention evaluation reports in a consistent and coherent manner, thereby improving evidence comparison, synthesis, replication, and implementation of effective interventions.
  • Keep on running - a randomized controlled trial to test a digital evidence-based intervention for sustained adoption of recreational running: rationale, design and pilot feasibility study.

    V Pereira, Hugo; Teixeira, Pedro J; Marques, Marta M; Carraça, Eliana V; Silva, Marlene N; Encantado, Jorge; Santos, Inês; Palmeira, António L (2021-03-01)
    Intervention development was based both on Self-Determination Theory and on Self-Regulation Theory. As part of it, a pilot study was implemented (n=18) to measure intervention adherence and participant satisfaction in order to establish the feasibility and acceptability of the intervention toolkit. Furthermore, this pilot study was also used to test the feasibility and acceptability of the questionnaires selected to be part of the later RCT.

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