Recent Submissions

  • A novel glucocorticoid-free maintenance regimen for anti-neutrophil cytoplasm antibody-associated vasculitis.

    Pepper, Ruth J; McAdoo, Stephen P; Moran, Sarah M; Kelly, Dearbhla; Scott, Jennifer; Hamour, Sally; Burns, Aine; Griffith, Megan; Galliford, Jack; Levy, Jeremy B; et al.
  • Hepatic Tumor Microenvironments and Effects on NK Cell Phenotype and Function.

    Piñeiro Fernández, Julián; Luddy, Kimberly A; Harmon, Cathal; O'Farrelly, Cliona (2019-08-24)
    The liver is a complex organ with critical physiological functions including metabolism, glucose storage, and drug detoxification. Its unique immune profile with large numbers of cytotoxic CD8+ T cells and significant innate lymphoid population, including natural killer cells, γ δ T cells, MAIT cells, and iNKTcells, suggests an important anti-tumor surveillance role. Despite significant immune surveillance in the liver, in particular large NK cell populations, hepatic cell carcinoma (HCC) is a relatively common outcome of chronic liver infection or inflammation. The liver is also the second most common site of metastatic disease. This discordance suggests immune suppression by the environments of primary and secondary liver cancers. Classic tumor microenvironments (TME) are poorly perfused, leading to accumulation of tumor cell metabolites, diminished O2, and decreased nutrient levels, all of which impact immune cell phenotype and function. Here, we focus on changes in the liver microenvironment associated with tumor presence and how they affect NK function and phenotype.
  • An evaluation of an interprofessional master's level programme in children's palliative care. Part 1 the students' evaluation of the programme.

    Nicholl, Honor; Price, Jayne; Tracey, Catherine (2014-04-01)
    In 2010/12 an innovative children's palliative care interprofessional educational project funded by the Irish Hospice Foundation was undertaken in a University faculty (Trinity College Dublin). This initiative responded to international educational recommendations to meet the palliative care needs of children. The project involved the development and delivery of 3 standalone modules at Master's level and a substantive research evaluation of the project to examine stakeholders and students perspectives to provide an insight into their experiences and to gather data for future developments. The research evaluation was conducted in two parts, part one sought students' evaluation and part two sought stakeholders', curriculum developers and lecturers' feedback. This paper reports the students' evaluation. Findings indicate that students perceived undertaking the modules provided them with the opportunity for improved interprofessional learning and they found modular content and assessment challenging. They also found the modules met their educational needs and also promoted an awareness of interprofessional education and the collaborative teamwork involved in children's palliative care. These students already experienced in children's palliative care indicated that those teaching on programmes at this level need expertise and programme time needs to be available for sharing experiences and for consolidation of learning.
  • Advancing years, Different challenges:Wave 2 IDS-TILDA: findings on the ageing of people with an intellectual disability: an intellectual disability supplement to the Irish Longitudinal Study on Ageing

    McCarron, Mary; McCallion, Philip; Carroll, Rachael; Burke, Eilish; Cleary, Eimear; McCausland, Darren; McGlinchy, Eimear; O’Donovan, May-Ann; Mulryan, Niamh; Shivers, Carolyn (School of Nursing and Midwifery, Trinity College Dublin., 2014-10)
  • Visible lives: Identifying the experiences and needs of older lesbian, gay, bisexual and transgender people in Ireland: key findings

    Gay & Lesbian Equality Network (GLEN); School of Nursing and Midwifery, Trinity College Dublin (2011)
  • Alzheimer's disease Abeta assemblies mediating rapid disruption of synaptic plasticity and memory

    Klyubin, Igor; Cullen, William K; Hu, Neng-Wei; Rowan, Michael J (2012-07-17)
    Abstract Alzheimer’s disease (AD) is characterized by episodic memory impairment that often precedes clinical diagnosis by many years. Probing the mechanisms of such impairment may provide much needed means of diagnosis and therapeutic intervention at an early, pre-dementia, stage. Prior to the onset of significant neurodegeneration, the structural and functional integrity of synapses in mnemonic circuitry is severely compromised in the presence of amyloidosis. This review examines recent evidence evaluating the role of amyloid-ß protein (Aβ) in causing rapid disruption of synaptic plasticity and memory impairment. We evaluate the relative importance of different sizes and conformations of Aβ, including monomer, oligomer, protofibril and fibril. We pay particular attention to recent controversies over the relevance to the pathophysiology of AD of different water soluble Aβ aggregates and the importance of cellular prion protein in mediating their effects. Current data are consistent with the view that both low-n oligomers and larger soluble assemblies present in AD brain, some of them via a direct interaction with cellular prion protein, cause synaptic memory failure. At the two extremes of aggregation, monomers and fibrils appear to act in vivo both as sources and sinks of certain metastable conformations of soluble aggregates that powerfully disrupt synaptic plasticity. The same principle appears to apply to other synaptotoxic amyloidogenic proteins including tau, α-synuclein and prion protein.