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    Adipose tissue as a key player in obstructive sleep apnoea.

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    Authors
    Ryan, Silke
    Arnaud, Claire
    Fitzpatrick, Susan F
    Gaucher, Jonathan
    Tamisier, Renaud
    Pépin, Jean-Louis
    Issue Date
    2019-06-26
    Keywords
    SLEEP APNOEA
    OBESITY
    
    Metadata
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    Journal
    European respiratory review : an official journal of the European Respiratory Society
    URI
    http://hdl.handle.net/10147/627165
    DOI
    10.1183/16000617.0006-2019
    PubMed ID
    31243096
    Abstract
    Obstructive sleep apnoea (OSA) is a major health concern worldwide and adversely affects multiple organs and systems. OSA is associated with obesity in >60% of cases and is independently linked with the development of numerous comorbidities including hypertension, arrhythmia, stroke, coronary heart disease and metabolic dysfunction. The complex interaction between these conditions has a significant impact on patient care and mortality. The pathophysiology of cardiometabolic complications in OSA is still incompletely understood; however, the particular form of intermittent hypoxia (IH) observed in OSA, with repetitive short cycles of desaturation and re-oxygenation, probably plays a pivotal role. There is fast growing evidence that IH mediates some of its detrimental effects through adipose tissue inflammation and dysfunction. This article aims to summarise the effects of IH on adipose tissue in experimental models in a comprehensive way. Data from well-designed controlled trials are also reported with the final goal of proposing new avenues for improving phenotyping and personalised care in OSA.
    Item Type
    Article
    Language
    en
    EISSN
    1600-0617
    ae974a485f413a2113503eed53cd6c53
    10.1183/16000617.0006-2019
    Scopus Count
    Collections
    St. Vincent's University Hospital

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