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dc.contributor.authorScott, Alasdair J
dc.contributor.authorAlexander, James L
dc.contributor.authorMerrifield, Claire A
dc.contributor.authorCunningham, David
dc.contributor.authorJobin, Christian
dc.contributor.authorBrown, Robert
dc.contributor.authorAlverdy, John
dc.contributor.authorO'Keefe, Stephen J
dc.contributor.authorGaskins, H Rex
dc.contributor.authorTeare, Julian
dc.contributor.authorYu, Jun
dc.contributor.authorHughes, David J
dc.contributor.authorVerstraelen, Hans
dc.contributor.authorBurton, Jeremy
dc.contributor.authorO'Toole, Paul W
dc.contributor.authorRosenberg, Daniel W
dc.contributor.authorMarchesi, Julian R
dc.contributor.authorKinross, James M
dc.date.accessioned2020-01-31T16:59:04Z
dc.date.available2020-01-31T16:59:04Z
dc.date.issued2019-05-15
dc.identifier.pmid31092590
dc.identifier.doi10.1136/gutjnl-2019-318556
dc.identifier.urihttp://hdl.handle.net/10147/627118
dc.descriptionObjective: In this consensus statement, an international panel of experts deliver their opinions on key questions regarding the contribution of the human microbiome to carcinogenesis. Design: International experts in oncology and/or microbiome research were approached by personal communication to form a panel. A structured, iterative, methodology based around a 1-day roundtable discussion was employed to derive expert consensus on key questions in microbiome-oncology research. Results: Some 18 experts convened for the roundtable discussion and five key questions were identified regarding: (1) the relevance of dysbiosis/an altered gut microbiome to carcinogenesis; (2) potential mechanisms of microbiota-induced carcinogenesis; (3) conceptual frameworks describing how the human microbiome may drive carcinogenesis; (4) causation versus association; and (5) future directions for research in the field.The panel considered that, despite mechanistic and supporting evidence from animal and human studies, there is currently no direct evidence that the human commensal microbiome is a key determinant in the aetiopathogenesis of cancer. The panel cited the lack of large longitudinal, cohort studies as a principal deciding factor and agreed that this should be a future research priority. However, while acknowledging gaps in the evidence, expert opinion was that the microbiome, alongside environmental factors and an epigenetically/genetically vulnerable host, represents one apex of a tripartite, multidirectional interactome that drives carcinogenesis. Conclusion: Data from longitudinal cohort studies are needed to confirm the role of the human microbiome as a key driver in the aetiopathogenesis of cancer.en_US
dc.language.isoenen_US
dc.rights© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
dc.subjectCANCERen_US
dc.subjectGUT MICROBIOMEen_US
dc.titleInternational Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis.en_US
dc.typeArticleen_US
dc.identifier.eissn1468-3288
dc.identifier.journalGuten_US
dc.source.journaltitleGut
dc.source.volume68
dc.source.issue9
dc.source.beginpage1624
dc.source.endpage1632
refterms.dateFOA2020-01-31T16:59:04Z
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited Kingdom
dc.source.countryUnited Kingdom
dc.source.countryEngland


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