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dc.contributor.authorCussotto, Sofia
dc.contributor.authorClarke, Gerard
dc.contributor.authorDinan, Timothy G
dc.contributor.authorCryan, John F
dc.date.accessioned2020-01-30T16:58:31Z
dc.date.available2020-01-30T16:58:31Z
dc.date.issued2019-02-26
dc.identifier.pmid30806744
dc.identifier.doi10.1007/s00213-019-5185-8
dc.identifier.urihttp://hdl.handle.net/10147/627106
dc.descriptionThe human gut contains trillions of symbiotic bacteria that play a key role in programming different aspects of host physiology in health and disease. Psychotropic medications act on the central nervous system (CNS) and are used in the treatment of various psychiatric disorders. There is increasing emphasis on the bidirectional interaction between drugs and the gut microbiome. An expanding body of evidence supports the notion that microbes can metabolise drugs and vice versa drugs can modify the gut microbiota composition. In this review, we will first give a comprehensive introduction about this bidirectional interaction, then we will take into consideration different classes of psychotropics including antipsychotics, antidepressants, antianxiety drugs, anticonvulsants/mood stabilisers, opioid analgesics, drugs of abuse, alcohol, nicotine and xanthines. The varying effects of these widely used medications on microorganisms are becoming apparent from in vivo and in vitro studies. This has important implications for the future of psychopharmacology pipelines that will routinely need to consider the host microbiome during drug discovery and development.en_US
dc.language.isoenen_US
dc.subjectAntidepressanten_US
dc.subjectAntimicrobialen_US
dc.subjectAntipsychoticen_US
dc.subjectPsychotropicen_US
dc.subjectPSYCHOTROPIC DRUGSen_US
dc.subjectGUT MICROBIOMEen_US
dc.titlePsychotropics and the Microbiome: a Chamber of Secrets….en_US
dc.typeArticleen_US
dc.identifier.eissn1432-2072
dc.identifier.journalPsychopharmacologyen_US
dc.source.journaltitlePsychopharmacology
dc.source.volume236
dc.source.issue5
dc.source.beginpage1411
dc.source.endpage1432
refterms.dateFOA2020-01-30T16:58:32Z
dc.source.countryIreland
dc.source.countryGermany


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