• Login
    View Item 
    •   Home
    • Hospital Research
    • Leinster
    • St. Luke's Radiation Oncology Network, Dublin
    • View Item
    •   Home
    • Hospital Research
    • Leinster
    • St. Luke's Radiation Oncology Network, Dublin
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    5081
    UlsterS
    5081
    Connacht
    1698
    Munster
    58
    Leinster
    466

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideNational Health Library & Knowledge ServiceGuide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementORCID Unique identifiers for ResearchersHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Glioblastoma Multiforme in the over 70's: "To treat or not to treat with radiotherapy?"

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Glynn_2019.pdf
    Size:
    296.3Kb
    Format:
    PDF
    Download
    Authors
    O'Shea, Julianne
    Dunne, Mary
    Grogan, Roger
    MacNally, Stephen
    Fitzpatrick, David
    Faul, Clare
    Glynn, Am
    Rangaswamy, Guhan
    Issue Date
    2019-07-04
    Keywords
    Glioblastoma
    Temozolomide
    age
    debulking
    performance status
    radiotherapy
    
    Metadata
    Show full item record
    URI
    http://hdl.handle.net/10147/624798
    DOI
    10.1002/cam4.2398
    PubMed ID
    31270955
    Abstract
    BACKGROUND: The incidence of Glioblastoma Multiforme (GBM) is increasing among the older population and is associated with poor prognosis. Management guidelines are lacking in this group. The purpose of this study was to analyze survival data and determine predictors of survival in patients aged ≥70 years treated with radiotherapy (RT) and/or Temozolomide. MATERIALS AND METHODS: A retrospective analysis of all GBM patients treated at our institution between January 2011 and January 2017 was carried out. RESULTS: One-hundred and four patients were eligible. Median age was 73.8 years (70-87). Thirty-three patients received radical RT and 71 palliative RT. Overall median survival (MS) was 6 months. The MS was 10.6 months for radical patients and 4.9 months for palliative patients (P < 0.0005). The MS was 6.9 months in patients aged 70-75 years and 5.2 months in those aged 76-80 years (P = 0.004). The debulked group had a statistically significantly longer survival (8.0 months) than the biopsy only group (4.9 months). Biopsy only (hazard ratio [HR] 2.4), ECOG performance status 3 vs 0 (HR 6.4), and increasing age (HR 1.06) were associated with statistically significant shorter survival after adjustment for the effects of concurrent chemo, delay in starting RT, and RT dose. CONCLUSION: The MS for radical patients was favorable and approaching current literature for the under 70 age group. Radical treatment should be considered for good performance patients aged 70-75 years. Increasing age was associated with shorter MS in patients aged ≥76 years. Debulking and good performance status were associated with improved survival.
    Item Type
    Article
    ISSN
    2045-7634
    ae974a485f413a2113503eed53cd6c53
    10.1002/cam4.2398
    Scopus Count
    Collections
    St. Luke's Radiation Oncology Network, Dublin

    entitlement

    Related articles

    • Elderly patients with glioblastoma multiforme treated with concurrent temozolomide and standard- versus abbreviated-course radiotherapy.
    • Authors: Chang-Halpenny CN, Yeh J, Lien WW
    • Issue date: 2015 Winter
    • Effectiveness of temozolomide treatment used at the same time with radiotherapy and adjuvant temozolomide; concomitant therapy of glioblastoma multiforme: multivariate analysis and other prognostic factors.
    • Authors: Birol Sarica F, Tufan K, Cekinmez M, Sen O, Cem Onal H, Mertsoylu H, Topkan E, Pehlivan B, Erdogan B, Nur Altinors M
    • Issue date: 2010 Mar
    • Treatment outcomes for patients with glioblastoma multiforme and a low Karnofsky Performance Scale score on presentation to a tertiary care institution. Clinical article.
    • Authors: Marina O, Suh JH, Reddy CA, Barnett GH, Vogelbaum MA, Peereboom DM, Stevens GH, Elinzano H, Chao ST
    • Issue date: 2011 Aug
    • Prognostic factors in glioblastoma multiforme. 10 years experience of a single institution.
    • Authors: Hulshof MC, Koot RW, Schimmel EC, Dekker F, Bosch DA, González González D
    • Issue date: 2001 Jun
    • Improved median survival for glioblastoma multiforme following introduction of adjuvant temozolomide chemotherapy.
    • Authors: Back MF, Ang EL, Ng WH, See SJ, Lim CC, Chan SP, Yeo TT
    • Issue date: 2007 May
    Health Library Ireland | Health Service Executive | Jervis House, Jervis Street | Republic of Ireland | Eircode: D01 W596
    lenus@hse.ie | Tel: +353-1-7786275
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.