Activation of a TLR9 mediated innate immune response in preeclampsia.
Publisher
Scientific ReportsJournal
Scientific ReportsDOI
10.1038/s41598-019-42551-wPubMed ID
30976066Abstract
Preeclampsia is a multisystemic disorder leading to the development of a placental ischemic microenvironment with a resultant increase in oxidative stress. There is evidence that mitochondrial dysfunction and the innate immune system both play a role in the pathophysiology of this disease. Mitochondrial DAMPs such as mtDNA bind specifc pattern recognition receptors such as Toll-like receptor 9 (TLR9) on the endosomal surface of immune cells, in particular neutrophils, subsequently activating them and triggering an innate response. We hypothesised that the exaggerated innate immune response seen in preeclampsia is provoked by dysfunctional mitochondria. Here we provide evidence that TLR9 activity is signifcantly increased at time of disease in women with preeclampsia. Furthermore, we show activation of neutrophil markers, Calprotectin, Myeloperoxidase (MPO), and IL-8 are signifcantly increased at time of disease compared to uncomplicated pregnancies. This research supports a potential role of TLR9 activation of an innate immune response evident in preeclampsia which may possibly be initially triggered by dysfunctional mitochondria.Item Type
ArticleLanguage
enISSN
2045-2322Sponsors
C. McCarthy and L.C. Kenny are supported by a Science FoundationIreland (SFI) Program Grant for INFANT (12/RC/2272) and HealthResearch Board Ireland, Health Research Award (HRA-POR-2015-1240) for fnancial supportae974a485f413a2113503eed53cd6c53
10.1038/s41598-019-42551-w
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